The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Plasminogen activator

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
T-plasminogen activator. [EC: 3.4.21.68]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • From a wide variety of mammalian tissues, especially endothelial cells.
  • Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin.
  • Activity is considerably enhanced by fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
9 A0A480NSF2 A0A480NSF2 P00750 P11214 P19637 Q28198 Q5R8J0 Q8SQ23 Q8SQ23