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CATH Superfamily 2.10.70.10

Complement Module, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: Complement component receptor type 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Complement component C4b binding GO:0001855
Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Complement component C4b receptor activity GO:0001861
Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Complement component C3b receptor activity GO:0004877
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement component C4b binding GO:0001855
Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement component C4b receptor activity GO:0001861
Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement component C3b receptor activity GO:0004877
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of complement activation, alternative pathway GO:0045957
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Negative regulation of complement activation, classical pathway GO:0045959
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Positive regulation of serine-type endopeptidase activity GO:1900005
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
 5 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) Q64735 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
 4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
 4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Negative regulation of complement activation, alternative pathway GO:0045957
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Negative regulation of complement activation, classical pathway GO:0045959
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Positive regulation of serine-type endopeptidase activity GO:1900005
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
 2 Q2VPA4 (/IDA) Q2VPA4 (/IDA)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
 2 Q63135 (/IMP) Q64735 (/IMP)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
 2 Q2VPA4 (/IDA) Q2VPA4 (/IDA)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
 1 Q64735 (/IGI)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
 1 Q64735 (/IMP)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
 1 Q64735 (/ISO)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
 1 Q64735 (/ISO)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
 1 Q64735 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
 20 F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS) F7D2W0 (/ISS)
(10 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
 4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
 4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 4 P17927 (/HDA) P17927 (/HDA) P17927 (/HDA) P17927 (/HDA)
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
 4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
 2 Q2VPA4 (/IDA) Q2VPA4 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
 1 Q64735 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
 1 Q64735 (/ISO)