The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Versican core protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 A4JYN2 (/IPI) P13608 (/IPI) P13611 (/IPI) P13611 (/IPI) P16112 (/IPI) Q61282 (/IPI)
Extracellular matrix structural constituent conferring compression resistance GO:0030021
A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.
5 F1SX59 (/RCA) P13611 (/RCA) P13611 (/RCA) P16112 (/RCA) Q62059 (/RCA)
Glycosaminoglycan binding GO:0005539
Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.
2 P13611 (/TAS) P13611 (/TAS)
Hyaluronic acid binding GO:0005540
Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2 P13611 (/TAS) P13611 (/TAS)
Extracellular matrix structural constituent conferring compression resistance GO:0030021
A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.
2 P13611 (/ISS) P13611 (/ISS)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 P16112 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P07897 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q61282 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 Q62059 (/IPI)
Low-density lipoprotein particle binding GO:0030169
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
1 Q9ERB4 (/TAS)

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
8 A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP)
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
8 A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP) A0A1D5NSM8 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
6 O14594 (/TAS) O14594 (/TAS) P13611 (/TAS) P13611 (/TAS) P16112 (/TAS) Q96GW7 (/TAS)
Chondroitin sulfate biosynthetic process GO:0030206
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
5 O14594 (/TAS) O14594 (/TAS) P13611 (/TAS) P13611 (/TAS) Q96GW7 (/TAS)
Chondroitin sulfate catabolic process GO:0030207
The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
5 O14594 (/TAS) O14594 (/TAS) P13611 (/TAS) P13611 (/TAS) Q96GW7 (/TAS)
Dermatan sulfate biosynthetic process GO:0030208
The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.
5 O14594 (/TAS) O14594 (/TAS) P13611 (/TAS) P13611 (/TAS) Q96GW7 (/TAS)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
4 E7F537 (/IMP) F1QDA1 (/IMP) Q58EI4 (/IMP) Q75ZI2 (/IMP)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
3 A0A2R8QK78 (/IMP) F1QFM9 (/IMP) Q75ZI3 (/IMP)
Intramembranous ossification GO:0001957
Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.
3 A0A2R8QK78 (/IMP) F1QFM9 (/IMP) Q75ZI3 (/IMP)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
2 P13611 (/HDA) P13611 (/HDA)
Regulation of glomerular filtration GO:0003093
Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.
2 A0A2R8Q3K1 (/IMP) Q1LXE5 (/IMP)
Endocardial cushion morphogenesis GO:0003203
The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
2 A0A2R8Q3K1 (/IMP) Q1LXE5 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 P13611 (/TAS) P13611 (/TAS)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 P13611 (/TAS) P13611 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 Q61282 (/IMP) Q62059 (/IMP)
Cell recognition GO:0008037
The process in which a cell in an organism interprets its surroundings.
2 P13611 (/TAS) P13611 (/TAS)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
2 F1R511 (/IMP) F8W252 (/IMP)
Pronephric glomerulus morphogenesis GO:0035775
The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
2 A0A2R8Q3K1 (/IMP) Q1LXE5 (/IMP)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
2 P13611 (/TAS) P13611 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
2 P13611 (/TAS) P13611 (/TAS)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
1 P16112 (/NAS)
Cartilage condensation GO:0001502
The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
1 Q61282 (/IMP)
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 P07897 (/IEP)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 Q62059 (/IEP)
Chondrocyte development GO:0002063
The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
1 Q61282 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P16112 (/NAS)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 P55068 (/IDA)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q61361 (/ISO)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P07897 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P55068 (/IEP)
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
1 Q62059 (/ISO)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
1 P07897 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 Q9ERB4 (/IEP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P07897 (/IEP)
Response to gravity GO:0009629
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
1 P07897 (/IEP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P07897 (/IEP)
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
1 P07897 (/IEP)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 P07897 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P07897 (/IEP)
Keratan sulfate biosynthetic process GO:0018146
The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
1 P16112 (/TAS)
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
1 P07897 (/IEP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q61361 (/IMP)
Proteoglycan biosynthetic process GO:0030166
The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
1 Q61282 (/IMP)
Collagen fibril organization GO:0030199
Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
1 Q61282 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 P07897 (/IDA)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q61282 (/ISO)
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
1 Q9ERB4 (/IEP)
Gliogenesis GO:0042063
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
1 P55068 (/IEP)
Keratan sulfate catabolic process GO:0042340
The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
1 P16112 (/TAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P07897 (/IEP)
Regulation of phosphoprotein phosphatase activity GO:0043666
Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.
1 Q62059 (/IDA)
Regulation of phosphoprotein phosphatase activity GO:0043666
Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.
1 Q62059 (/ISO)
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 P55068 (/IEP)
Regulation of synapse structural plasticity GO:0051823
Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane.
1 P55066 (/IMP)
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
1 Q61361 (/IDA)
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
1 Q61361 (/IMP)
Chondroblast differentiation GO:0060591
The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.
1 P07897 (/IEP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 P07897 (/IEP)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P55068 (/IDA)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q61361 (/ISO)

There are 44 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
7 O14594 (/TAS) O14594 (/TAS) P13608 (/TAS) P13611 (/TAS) P13611 (/TAS) P16112 (/TAS) Q96GW7 (/TAS)
Golgi lumen GO:0005796
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
6 O14594 (/TAS) O14594 (/TAS) P13611 (/TAS) P13611 (/TAS) P16112 (/TAS) Q96GW7 (/TAS)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
6 O14594 (/TAS) O14594 (/TAS) P13611 (/TAS) P13611 (/TAS) P16112 (/TAS) Q96GW7 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P13611 (/HDA) P13611 (/HDA) Q61282 (/HDA) Q62059 (/HDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
4 P13611 (/HDA) P13611 (/HDA) P16112 (/HDA) Q62059 (/HDA)
Perineuronal net GO:0072534
A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.
4 P07897 (/IDA) P55067 (/IDA) P55068 (/IDA) Q9ERB4 (/IDA)
Perineuronal net GO:0072534
A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.
4 P55066 (/ISO) Q61282 (/ISO) Q61361 (/ISO) Q62059 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
3 Q61282 (/IDA) Q61361 (/IDA) Q62059 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 P55067 (/IDA) P55068 (/IDA) Q9ERB4 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 P55066 (/ISO) Q61361 (/ISO) Q62059 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 P55068 (/IDA) Q61282 (/IDA) Q61361 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P13611 (/HDA) P13611 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07897 (/IDA) P55068 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q61282 (/ISO) Q61361 (/ISO)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 P13611 (/TAS) P13611 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P55066 (/TAS) P55067 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P55068 (/IDA) Q9ERB4 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q61361 (/ISO) Q62059 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P13611 (/HDA) P13611 (/HDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
2 P13611 (/TAS) P13611 (/TAS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 P55067 (/EXP) Q9ERB4 (/EXP)
Perisynaptic extracellular matrix GO:0098966
The portion of the extracellular matrix that lies within the perisynaptic space.
2 P55068 (/IDA) Q61282 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
2 P55068 (/IDA) Q61282 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q61282 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P55068 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q61361 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P55068 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q61361 (/ISO)
Anchored component of membrane GO:0031225
The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 P55068 (/IDA)
Anchored component of membrane GO:0031225
The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 Q61361 (/ISO)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
1 P55068 (/IDA)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
1 Q61361 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P07897 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q61282 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P07897 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q61282 (/ISO)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
1 P55068 (/IDA)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
1 Q61361 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 Q9ERB4 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 Q62059 (/ISO)
Perisynaptic extracellular matrix GO:0098966
The portion of the extracellular matrix that lies within the perisynaptic space.
1 Q61361 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q61361 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q61361 (/ISO)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q61361 (/ISO)