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CATH Superfamily 2.10.70.10

Complement Module, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: Complement factor b,-like

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alternative-complement-pathway C3/C5 convertase. [EC: 3.4.21.47]
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha- chain to yield C5a and C5b.
  • A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site.
  • Bb is formed by cleavage of proenzyme factor B by factor D.
  • Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex.
  • C3b,Bb is stabilized in plasma by factor P.
  • Belongs to peptidase family S1.
 28 A0A1U9X7H8 A0A1U9X7H8 A0A1U9X7H8 A0A1U9X7H8 K7D3S4 K7D3S4 K7D3S4 K7D3S4 P00751 P00751
(18 more...)
Classical-complement-pathway C3/C5 convertase. [EC: 3.4.21.43]
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
  • A complex of complement fragments C4b, C2a and C2b.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.44.
 16 P06681 P06681 P06681 P06681 P21180 P21180 Q5JP69 Q5JP69 Q5JP69 Q5JP69
(6 more...)