The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Membrane cofactor protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 29 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
17 P04003 (/IPI) P04003 (/IPI) P15529 (/IPI) P19070 (/IPI) P19070 (/IPI) P19070 (/IPI) P19070 (/IPI) P19070 (/IPI) P20023 (/IPI) P20023 (/IPI)
(7 more)
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Complement component C4b binding GO:0001855
Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Complement component C4b receptor activity GO:0001861
Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Complement component C3b receptor activity GO:0004877
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
6 O88174 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
5 P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO)
Complement receptor activity GO:0004875
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
5 P19070 (/IMP) P19070 (/IMP) P19070 (/IMP) P19070 (/IMP) P19070 (/IMP)
Complement receptor activity GO:0004875
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
5 P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS)
Complement receptor activity GO:0004875
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
5 P20023 (/TAS) P20023 (/TAS) P20023 (/TAS) P20023 (/TAS) P20023 (/TAS)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
5 P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
5 P19070 (/IDA) P19070 (/IDA) P19070 (/IDA) P19070 (/IDA) P19070 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO)
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement component C4b binding GO:0001855
Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement component C4b receptor activity GO:0001861
Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement component C3b receptor activity GO:0004877
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
2 Q63514 (/TAS) Q63514 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P04003 (/HDA) P04003 (/HDA)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 A0A024CBD6 (/IDA) O02839 (/IDA)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
2 O08569 (/NAS) O08569 (/NAS)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
1 Q9Z0M4 (/IPI)
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
1 E1JHA6 (/IPI)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 P15529 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P15529 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 O88174 (/ISO)

There are 67 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
13 P04003 (/TAS) P04003 (/TAS) P15529 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P20023 (/TAS) P20023 (/TAS) P20023 (/TAS)
(3 more)
Negative regulation of complement activation, alternative pathway GO:0045957
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Negative regulation of complement activation, classical pathway GO:0045959
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.
8 A0A024CBD6 (/IDA) O02839 (/IDA) P04003 (/IDA) P04003 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Negative regulation of complement activation, classical pathway GO:0045959
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Positive regulation of serine-type endopeptidase activity GO:1900005
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
6 Q60736 (/IMP) Q60736 (/IMP) Q60736 (/IMP) Q60736 (/IMP) Q7TSY4 (/IMP) Q7TSY4 (/IMP)
Negative regulation of complement activation, alternative pathway GO:0045957
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.
6 A0A024CBD6 (/IDA) O02839 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
5 P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
5 P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
5 P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
5 P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
5 P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO)
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
5 P19070 (/IMP) P19070 (/IMP) P19070 (/IMP) P19070 (/IMP) P19070 (/IMP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
4 Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
4 Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
4 Q60736 (/ISO) Q60736 (/ISO) Q60736 (/ISO) Q60736 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Positive regulation of serine-type endopeptidase activity GO:1900005
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 A0A024CBD6 (/IDA) O02839 (/IDA) Q9Z0M4 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 Q63514 (/TAS) Q63514 (/TAS)
Organelle organization GO:0006996
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
2 O08569 (/NAS) O08569 (/NAS)
Acrosome reaction GO:0007340
The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
2 O08569 (/NAS) O08569 (/NAS)
Response to symbiotic bacterium GO:0009609
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.
2 P04003 (/IDA) P04003 (/IDA)
Regulation of tube architecture, open tracheal system GO:0035152
Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network.
2 E1JHA6 (/IMP) Q9VM55 (/IMP)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
2 P04003 (/IDA) P04003 (/IDA)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
2 E1JHA6 (/IGI) Q9VM55 (/IGI)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
2 Q63135 (/IMP) Q64735 (/IMP)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
2 O88174 (/ISO) Q64735 (/ISO)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
2 E1JHA6 (/IMP) Q9VM55 (/IMP)
Regulation of opsonization GO:1903027
Any process that modulates the frequency, rate or extent of opsonization.
2 P04003 (/IDA) P04003 (/IDA)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q64735 (/IGI)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
1 P15529 (/IC)
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
1 P15529 (/IMP)
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
1 O88174 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O88174 (/ISO)
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
1 P15529 (/IDA)
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
1 O88174 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P15529 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O88174 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P15529 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O88174 (/ISO)
Sensory organ precursor cell fate determination GO:0016360
The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed.
1 E1JHA6 (/IMP)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 Q2VPA4 (/IDA)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 Q64735 (/IMP)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 Q64735 (/ISO)
Interleukin-10 production GO:0032613
The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 P15529 (/IDA)
Interleukin-10 production GO:0032613
The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 O88174 (/ISO)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
1 P15529 (/IDA)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
1 O88174 (/ISO)
Sequestering of extracellular ligand from receptor GO:0035581
The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.
1 P15529 (/IDA)
Sequestering of extracellular ligand from receptor GO:0035581
The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.
1 O88174 (/ISO)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P15529 (/IDA)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 O88174 (/ISO)
Positive regulation of memory T cell differentiation GO:0043382
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
1 P15529 (/IDA)
Positive regulation of memory T cell differentiation GO:0043382
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
1 O88174 (/ISO)
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
1 E1JHA6 (/IMP)
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
1 P15529 (/IDA)
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
1 O88174 (/ISO)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
1 Q9Z0M4 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q20531 (/IMP)
Positive regulation of transforming growth factor beta production GO:0071636
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.
1 P15529 (/IDA)
Positive regulation of transforming growth factor beta production GO:0071636
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.
1 O88174 (/ISO)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
1 Q2VPA4 (/IDA)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
1 Q64735 (/ISO)

There are 42 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 P04003 (/TAS) P04003 (/TAS) P15529 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P20023 (/TAS) P20023 (/TAS) P20023 (/TAS)
(2 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
10 P15529 (/HDA) P17927 (/HDA) P17927 (/HDA) P17927 (/HDA) P17927 (/HDA) P20023 (/HDA) P20023 (/HDA) P20023 (/HDA) P20023 (/HDA) P20023 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
8 Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29528 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS) Q29530 (/ISS)
Acrosomal matrix GO:0043159
A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.
8 O08569 (/IDA) O08569 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q7TSY4 (/IDA) Q7TSY4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P15529 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
6 P19070 (/IDA) P19070 (/IDA) P19070 (/IDA) P19070 (/IDA) P19070 (/IDA) Q64735 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 P15529 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) Q9Z0M4 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) P20023 (/IDA) Q2VPA4 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) P19070 (/ISO) Q64735 (/ISO)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
5 Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q9Z0M4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P15529 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS) P20023 (/NAS)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
4 Q60736 (/EXP) Q60736 (/EXP) Q60736 (/EXP) Q60736 (/EXP)
Outer acrosomal membrane GO:0002081
The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.
4 Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA)
Zona pellucida receptor complex GO:0002199
A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
4 Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P17927 (/IDA) P17927 (/IDA) P17927 (/IDA) P17927 (/IDA)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Acrosomal matrix GO:0043159
A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.
4 Q60736 (/ISO) Q60736 (/ISO) Q60736 (/ISO) Q60736 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
4 Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA) Q60736 (/IDA)
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
4 P17927 (/TAS) P17927 (/TAS) P17927 (/TAS) P17927 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P04003 (/NAS) P04003 (/NAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P04003 (/HDA) P04003 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P04003 (/IDA) P04003 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 A0A024CBD6 (/IDA) O02839 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 E1JHA6 (/IDA) Q9VM55 (/IDA)
Synaptic cleft GO:0043083
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
2 B7YZX0 (/IDA) Q8INW2 (/IDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
2 P04003 (/HDA) P04003 (/HDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 O88174 (/ISO)
Inner acrosomal membrane GO:0002079
The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.
1 Q9Z0M4 (/IDA)
Inner acrosomal membrane GO:0002079
The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.
1 O88174 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Z0M4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O88174 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9Z0M4 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O88174 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O88174 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P15529 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P15529 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 O88174 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q9Z0M4 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 O88174 (/ISO)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 E1JHA6 (/IDA)