The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CD59
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Receptor protein serine/threonine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activin receptor activity, type I GO:0016361
Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
2 P70539 (/IDA) Q8NER5 (/IDA)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
2 P70539 (/ISS) Q8K348 (/ISS)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
2 P70539 (/IC) Q8NER5 (/IC)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P70539 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q8K348 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q8NER5 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P70539 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q8K348 (/ISO)
Activin receptor activity, type I GO:0016361
Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
1 Q8K348 (/ISO)
Activin receptor activity, type I GO:0016361
Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
1 Q8K348 (/ISS)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 Q8NER5 (/IPI)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 Q8K348 (/ISO)
Nodal binding GO:0038100
Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily.
1 Q8NER5 (/IMP)
Nodal binding GO:0038100
Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily.
1 Q8K348 (/ISO)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 P70539 (/IDA)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 Q8K348 (/ISO)
Activin binding GO:0048185
Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
1 P70539 (/IDA)
Activin binding GO:0048185
Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
1 Q8K348 (/ISO)
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
1 P70539 (/IDA)
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
1 Q8K348 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P70539 (/IC) Q8NER5 (/IC)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2 P70539 (/IDA) Q8NER5 (/IDA)
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
1 P70539 (/IEP)
Trophectodermal cell proliferation GO:0001834
The proliferation of cells in the trophectoderm.
1 Q8K348 (/ISO)
Response to dietary excess GO:0002021
The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
1 Q8K348 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P70539 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q8K348 (/ISO)
Transforming growth factor beta receptor complex assembly GO:0007181
The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.
1 P70539 (/IDA)
Transforming growth factor beta receptor complex assembly GO:0007181
The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.
1 Q8K348 (/ISO)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P70539 (/IEP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q8K348 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P70539 (/IEP)
Lipid storage GO:0019915
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 Q8K348 (/IMP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 P70539 (/IEP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 P70539 (/IEP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q8K348 (/ISO)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q8K348 (/ISS)
Apoptotic nuclear changes GO:0030262
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
1 Q8NER5 (/IDA)
Apoptotic nuclear changes GO:0030262
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
1 Q8K348 (/ISO)
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
1 P70539 (/IEP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q8K348 (/IMP)
Response to lipid GO:0033993
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
1 P70539 (/IEP)
Nodal signaling pathway GO:0038092
A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q8NER5 (/IMP)
Nodal signaling pathway GO:0038092
A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q8K348 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P70539 (/IEP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 P70539 (/IDA)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q8K348 (/ISO)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q8K348 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q8K348 (/ISO)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q8NER5 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q8K348 (/ISO)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
1 Q8K348 (/IMP)
Negative regulation of trophoblast cell migration GO:1901164
Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.
1 Q8NER5 (/IDA)
Negative regulation of trophoblast cell migration GO:1901164
Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.
1 Q8K348 (/ISO)
Negative regulation of chorionic trophoblast cell proliferation GO:1901383
Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation.
1 Q8NER5 (/IMP)
Negative regulation of chorionic trophoblast cell proliferation GO:1901383
Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation.
1 Q8K348 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8K348 (/TAS) Q8NER5 (/TAS)
Activin receptor complex GO:0048179
A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
2 P70539 (/IDA) Q8NER5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P70539 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8K348 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70539 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8K348 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P70539 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8K348 (/ISO)
Activin receptor complex GO:0048179
A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
1 Q8K348 (/ISO)
Activin receptor complex GO:0048179
A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
1 Q8K348 (/ISS)