The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tumor Necrosis Factor Receptor, subunit A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: Tumor necrosis factor receptor superfamily member ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O19131 (/IPI) P19438 (/IPI) P22934 (/IPI) P25118 (/IPI) P25118 (/IPI)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
3 P22934 (/IMP) P25118 (/IMP) P25118 (/IMP)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
3 O19131 (/ISS) P22934 (/ISS) P50555 (/ISS)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
3 P19438 (/TAS) P25118 (/TAS) P25118 (/TAS)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P25118 (/ISO) P25118 (/ISO)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
2 P25118 (/IPI) P25118 (/IPI)
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
2 P25118 (/ISO) P25118 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P25118 (/ISO) P25118 (/ISO)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
2 P19438 (/IPI) P22934 (/IPI)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
2 P25118 (/ISO) P25118 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P25118 (/ISO) P25118 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P22934 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P22934 (/IPI)

There are 70 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
4 O19131 (/ISS) P19438 (/ISS) P22934 (/ISS) P50555 (/ISS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
3 O19131 (/ISS) P22934 (/ISS) P50555 (/ISS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 O19131 (/ISS) P22934 (/ISS) P50555 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P19438 (/IMP) P25118 (/IMP) P25118 (/IMP)
Aortic valve development GO:0003176
The progression of the aortic valve over time, from its formation to the mature structure.
2 P25118 (/IGI) P25118 (/IGI)
Pulmonary valve development GO:0003177
The progression of the pulmonary valve over time, from its formation to the mature structure.
2 P25118 (/IGI) P25118 (/IGI)
Negative regulation of extracellular matrix constituent secretion GO:0003332
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
2 P25118 (/IGI) P25118 (/IGI)
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
2 P25118 (/TAS) P25118 (/TAS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
2 P25118 (/IMP) P25118 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 P25118 (/IMP) P25118 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P25118 (/IMP) P25118 (/IMP)
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
2 P25118 (/IMP) P25118 (/IMP)
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
2 P25118 (/IGI) P25118 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P25118 (/ISO) P25118 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P25118 (/ISO) P25118 (/ISO)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P25118 (/IMP) P25118 (/IMP)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
2 P25118 (/ISO) P25118 (/ISO)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P19438 (/IMP) P22934 (/IMP)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P25118 (/ISO) P25118 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 P25118 (/IMP) P25118 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
2 P25118 (/ISO) P25118 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P25118 (/ISO) P25118 (/ISO)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 P25118 (/IMP) P25118 (/IMP)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P25118 (/ISO) P25118 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 P25118 (/ISO) P25118 (/ISO)
Positive regulation of apoptotic process involved in morphogenesis GO:1902339
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.
2 P25118 (/IGI) P25118 (/IGI)
Regulation of establishment of endothelial barrier GO:1903140
Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.
2 P25118 (/ISO) P25118 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P22934 (/IEP)
Aortic valve development GO:0003176
The progression of the aortic valve over time, from its formation to the mature structure.
1 P19438 (/ISS)
Pulmonary valve development GO:0003177
The progression of the pulmonary valve over time, from its formation to the mature structure.
1 P19438 (/ISS)
Negative regulation of extracellular matrix constituent secretion GO:0003332
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
1 P19438 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P22934 (/IEP)
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
1 P19438 (/TAS)
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
1 P19438 (/TAS)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P22934 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P22934 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P22934 (/IDA)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
1 P19438 (/TAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P19438 (/TAS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P22934 (/IEP)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
1 P22934 (/IDA)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 P22934 (/IMP)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P19438 (/TAS)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 P19438 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 P22934 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P22934 (/IMP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 P19438 (/IEP)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 P22934 (/IEP)
Response to alkaloid GO:0043279
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
1 P22934 (/IEP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 P22934 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P22934 (/IEP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P22934 (/IMP)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 P19438 (/IMP)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P22934 (/IPI)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P19438 (/IEP)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P22934 (/IEP)
Death-inducing signaling complex assembly GO:0071550
A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.
1 P19438 (/TAS)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 P19438 (/IMP)
Positive regulation of apoptotic process involved in morphogenesis GO:1902339
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.
1 P19438 (/ISS)
Regulation of establishment of endothelial barrier GO:1903140
Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.
1 P19438 (/IMP)
Positive regulation of ceramide biosynthetic process GO:2000304
Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.
1 P19438 (/TAS)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
5 O19131 (/ISS) P22934 (/ISS) P25118 (/ISS) P25118 (/ISS) P50555 (/ISS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 P19438 (/IDA) P22934 (/IDA) P25118 (/IDA) P25118 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P19438 (/TAS) P25118 (/TAS) P25118 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 P22934 (/IDA) P25118 (/IDA) P25118 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 P25118 (/ISO) P25118 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P19438 (/IDA) P22934 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P25118 (/ISO) P25118 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P25118 (/ISO) P25118 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P25118 (/ISO) P25118 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P25118 (/ISO) P25118 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P25118 (/ISO) P25118 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 P25118 (/ISO) P25118 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P25118 (/ISO) P25118 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P25118 (/ISO) P25118 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 P25118 (/ISO) P25118 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 P25118 (/ISO) P25118 (/ISO)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 P19438 (/IDA)
Tumor necrosis factor receptor superfamily complex GO:0002947
A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.
1 P19438 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P19438 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P19438 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P22934 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P22934 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P22934 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P19438 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P19438 (/TAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P22934 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P22934 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P19438 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P22934 (/IDA)