The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Laminin
".
FunFam 501: Crumbs 2, cell polarity complex component
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q80YA8 (/IPI) |
|
Aspartic-type endopeptidase inhibitor activity GO:0019828
Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
|
1 | Q5IJ48 (/IMP) |
|
Aspartic-type endopeptidase inhibitor activity GO:0019828
Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
|
1 | Q80YA8 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q5IJ48 (/IMP) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q80YA8 (/ISO) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Cardiovascular system development GO:0072358
The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.
|
8 | D4A3W2 (/ISS) F1N2V0 (/ISS) F1SKU3 (/ISS) F7HE09 (/ISS) H0XLX5 (/ISS) H2R133 (/ISS) I3NFS4 (/ISS) Q5IJ48 (/ISS) |
|
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
|
1 | Q80YA8 (/IMP) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q80YA8 (/IMP) |
|
Regulation of gastrulation GO:0010470
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
|
1 | Q80YA8 (/IMP) |
|
Regulation of gastrulation GO:0010470
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
|
1 | Q5IJ48 (/ISS) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
1 | Q80YA8 (/IMP) |
|
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
1 | Q5IJ48 (/IMP) |
|
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
1 | Q80YA8 (/ISO) |
|
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
|
1 | Q80YA8 (/IMP) |
|
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
|
1 | Q80YA8 (/IMP) |
|
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
|
1 | Q80YA8 (/IMP) |
|
Ingression involved in gastrulation with mouth forming second GO:0055111
The migration of individual cells into the embryo involved in deuterostomic gastrulation.
|
1 | Q80YA8 (/IMP) |
|
Ingression involved in gastrulation with mouth forming second GO:0055111
The migration of individual cells into the embryo involved in deuterostomic gastrulation.
|
1 | Q5IJ48 (/ISS) |
|
Cardiovascular system development GO:0072358
The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.
|
1 | Q80YA8 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q80YA8 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q5IJ48 (/ISS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q5IJ48 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q80YA8 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q5IJ48 (/HDA) |