The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 427: epigen isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
5 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA) Q924X1 (/IDA) Q924X1 (/IDA)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
5 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA) Q924X1 (/IDA) Q924X1 (/IDA)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 D3Z9P6 (/ISS)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 D3Z9P6 (/ISS)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of epidermal growth factor-activated receptor activity GO:0045741
Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.
5 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA) Q924X1 (/IDA) Q924X1 (/IDA)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
5 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA) Q924X1 (/IDA) Q924X1 (/IDA)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
4 D3Z9P6 (/ISS) Q6UW88 (/ISS) Q6UW88 (/ISS) Q6UW88 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
3 Q6UW88 (/ISS) Q6UW88 (/ISS) Q6UW88 (/ISS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
3 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
3 D3Z9P6 (/ISS) Q924X1 (/ISS) Q924X1 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
3 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
3 D3Z9P6 (/ISS) Q924X1 (/ISS) Q924X1 (/ISS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2 Q924X1 (/IDA) Q924X1 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
2 Q924X1 (/IDA) Q924X1 (/IDA)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Positive regulation of epidermal growth factor-activated receptor activity GO:0045741
Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
2 Q924X1 (/ISO) Q924X1 (/ISO)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
2 Q924X1 (/IDA) Q924X1 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 D3Z9P6 (/ISS)
Positive regulation of epidermal growth factor-activated receptor activity GO:0045741
Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.
1 D3Z9P6 (/ISS)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
1 D3Z9P6 (/ISS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q6UW88 (/IDA) Q6UW88 (/IDA) Q6UW88 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 D3Z9P6 (/ISS) Q924X1 (/ISS) Q924X1 (/ISS)
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
3 Q6UW88 (/TAS) Q6UW88 (/TAS) Q6UW88 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q924X1 (/ISO) Q924X1 (/ISO)