The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 201: EGF-containing fibulin-like extracellular matrix p...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O35568 (/IPI) O95967 (/IPI) O95967 (/IPI) Q12805 (/IPI) Q12805 (/IPI) Q12805 (/IPI) Q9WVJ9 (/IPI) Q9WVJ9 (/IPI)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
6 O95967 (/RCA) O95967 (/RCA) Q12805 (/RCA) Q12805 (/RCA) Q12805 (/RCA) Q8BPB5 (/RCA)
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
2 O95967 (/TAS) O95967 (/TAS)
Extracellular matrix constituent conferring elasticity GO:0030023
A component of the extracellular matrix that enables the matrix to recoil after transient stretching.
2 Q9WVJ9 (/RCA) Q9WVJ9 (/RCA)
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q8BPB5 (/ISO)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 Q8BPB5 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
3 Q12805 (/TAS) Q12805 (/TAS) Q12805 (/TAS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
3 Q12805 (/IEP) Q12805 (/IEP) Q12805 (/IEP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
3 Q12805 (/IEP) Q12805 (/IEP) Q12805 (/IEP)
Post-embryonic eye morphogenesis GO:0048050
The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.
3 Q12805 (/IEP) Q12805 (/IEP) Q12805 (/IEP)
Elastic fiber assembly GO:0048251
Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.
2 Q9WVJ9 (/IMP) Q9WVJ9 (/IMP)
Artery development GO:0060840
The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.
2 Q9WVJ9 (/IMP) Q9WVJ9 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8BPB5 (/ISO)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q8BPB5 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 O35568 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q8BPB5 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O35568 (/IDA)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q8BPB5 (/ISO)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 Q8BPB5 (/ISO)
Positive regulation of cell projection organization GO:0031346
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
1 O35568 (/IDA)
Positive regulation of cell projection organization GO:0031346
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
1 O35568 (/IMP)
Positive regulation of cell projection organization GO:0031346
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
1 Q8BPB5 (/ISO)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
1 Q8BPB5 (/ISO)
Regulation of glial cell migration GO:1903975
Any process that modulates the frequency, rate or extent of glial cell migration.
1 O35568 (/IDA)
Regulation of glial cell migration GO:1903975
Any process that modulates the frequency, rate or extent of glial cell migration.
1 Q8BPB5 (/ISO)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
9 O35568 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q7YQD7 (/ISS) Q8BPB5 (/ISS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
8 O95967 (/HDA) O95967 (/HDA) Q12805 (/HDA) Q12805 (/HDA) Q12805 (/HDA) Q8BPB5 (/HDA) Q9WVJ9 (/HDA) Q9WVJ9 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 Q12805 (/HDA) Q12805 (/HDA) Q12805 (/HDA) Q8BPB5 (/HDA) Q9WVJ9 (/HDA) Q9WVJ9 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 O95967 (/TAS) O95967 (/TAS) Q12805 (/TAS) Q12805 (/TAS) Q12805 (/TAS)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
5 Q12805 (/TAS) Q12805 (/TAS) Q12805 (/TAS) Q9WVJ9 (/TAS) Q9WVJ9 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 O95967 (/HDA) O95967 (/HDA) Q12805 (/HDA) Q12805 (/HDA) Q12805 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q12805 (/HDA) Q12805 (/HDA) Q12805 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q12805 (/IDA) Q12805 (/IDA) Q12805 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
2 O95967 (/TAS) O95967 (/TAS)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
2 O95967 (/HDA) O95967 (/HDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 O35568 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q8BPB5 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8BPB5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O35568 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BPB5 (/ISO)