The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 108: Fibulin-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 25 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
7 P23142 (/RCA) P37889 (/RCA) P37889 (/RCA) P37889 (/RCA) P98095 (/RCA) Q08879 (/RCA) Q08879 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P37889 (/IPI) P37889 (/IPI) P37889 (/IPI) Q08879 (/IPI) Q08879 (/IPI)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
3 P37889 (/IDA) P37889 (/IDA) P37889 (/IDA)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
2 Q08879 (/ISO) Q08879 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 Q08879 (/ISO) Q08879 (/ISO)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
2 Q08879 (/ISO) Q08879 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q08879 (/ISO) Q08879 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
2 Q08879 (/ISO) Q08879 (/ISO)
Peptidase activator activity GO:0016504
Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
2 Q08879 (/IDA) Q08879 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q08879 (/ISO) Q08879 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 Q08879 (/ISO) Q08879 (/ISO)
Fibrinogen binding GO:0070051
Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.
2 Q08879 (/ISO) Q08879 (/ISO)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
1 P23142 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q8NBH6 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q8NBH6 (/IPI)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 P23142 (/IDA)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 P98095 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P23142 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P98095 (/TAS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P23142 (/IPI)
Extracellular matrix constituent conferring elasticity GO:0030023
A component of the extracellular matrix that enables the matrix to recoil after transient stretching.
1 P98095 (/ISS)
Extracellular matrix constituent conferring elasticity GO:0030023
A component of the extracellular matrix that enables the matrix to recoil after transient stretching.
1 P98095 (/RCA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P23142 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P23142 (/IPI)
Fibrinogen binding GO:0070051
Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.
1 P23142 (/IPI)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
3 P37889 (/IDA) P37889 (/IDA) P37889 (/IDA)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 Q08879 (/ISO) Q08879 (/ISO)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
2 B1WC21 (/IEP) D3ZQ25 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q08879 (/ISO) Q08879 (/ISO)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
2 Q08879 (/IDA) Q08879 (/IDA)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q08879 (/ISO) Q08879 (/ISO)
Blood coagulation, fibrin clot formation GO:0072378
A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of transformation of host cell by virus GO:1904188
Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus.
2 Q08879 (/ISO) Q08879 (/ISO)
Positive regulation of substrate-dependent cell migration, cell attachment to substrate GO:1904237
Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of cell motility GO:2000146
Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of stem cell proliferation GO:2000647
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of transforming growth factor-beta secretion GO:2001202
Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion.
2 Q08879 (/ISO) Q08879 (/ISO)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P23142 (/IDA)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
1 P23142 (/IDA)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
1 O42182 (/IGI)
Embryonic medial fin morphogenesis GO:0035122
The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming.
1 O42182 (/IGI)
Skin morphogenesis GO:0043589
The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
1 O42182 (/IGI)
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 F1NWN4 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P23142 (/IDA)
Blood coagulation, fibrin clot formation GO:0072378
A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.
1 P23142 (/IDA)
Mesenchymal cell migration GO:0090497
The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.
1 O42182 (/IGI)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 P23142 (/IDA)
Negative regulation of cell motility GO:2000146
Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
1 P23142 (/IDA)
Negative regulation of stem cell proliferation GO:2000647
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.
1 P23142 (/IDA)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
7 P23142 (/HDA) P37889 (/HDA) P37889 (/HDA) P37889 (/HDA) P98095 (/HDA) Q08879 (/HDA) Q08879 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P23142 (/HDA) P37889 (/HDA) P37889 (/HDA) P37889 (/HDA) Q08879 (/HDA) Q08879 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P23142 (/HDA) P98095 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P23142 (/TAS) P98095 (/TAS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
2 Q08879 (/IDA) Q08879 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q08879 (/ISO) Q08879 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
2 Q08879 (/ISO) Q08879 (/ISO)
Elastic fiber GO:0071953
An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.
2 Q08879 (/ISO) Q08879 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P23142 (/NAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P23142 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P23142 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P98095 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P23142 (/HDA)
Elastic fiber GO:0071953
An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.
1 P23142 (/IDA)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
1 P98095 (/HDA)