The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: Tyrosine-protein kinase receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Insulin-like growth factor binding GO:0005520
Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
9 A0A0R4IGP2 (/IPI) A0A286Y9P5 (/IPI) A0A2R8Q206 (/IPI) A0A2R8Q844 (/IPI) A0A2R8QM53 (/IPI) A0A2R8QR15 (/IPI) B0R0Q2 (/IPI) B3DK52 (/IPI) Q1LWJ4 (/IPI)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
9 A0A0R4IGP2 (/IGI) A0A286Y9P5 (/IGI) A0A2R8Q206 (/IGI) A0A2R8Q844 (/IGI) A0A2R8QM53 (/IGI) A0A2R8QR15 (/IGI) B0R0Q2 (/IGI) B3DK52 (/IGI) Q1LWJ4 (/IGI)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 O73798 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 O73798 (/ISS)
Insulin-like growth factor-activated receptor activity GO:0005010
Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 O73798 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O73798 (/IPI)
Insulin-like growth factor binding GO:0005520
Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
1 O73798 (/IDA)
Insulin-like growth factor binding GO:0005520
Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
1 O73798 (/ISS)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 O73798 (/ISS)
Insulin receptor substrate binding GO:0043560
Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
1 O73798 (/ISS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Insulin-like growth factor receptor signaling pathway GO:0048009
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
10 A0A0R4IGP2 (/IDA) A0A286Y9P5 (/IDA) A0A2R8Q206 (/IDA) A0A2R8Q844 (/IDA) A0A2R8QM53 (/IDA) A0A2R8QR15 (/IDA) B0R0Q2 (/IDA) B3DK52 (/IDA) O73798 (/IDA) Q1LWJ4 (/IDA)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
9 A0A0R4IGP2 (/IGI) A0A286Y9P5 (/IGI) A0A2R8Q206 (/IGI) A0A2R8Q844 (/IGI) A0A2R8QM53 (/IGI) A0A2R8QR15 (/IGI) B0R0Q2 (/IGI) B3DK52 (/IGI) Q1LWJ4 (/IGI)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
9 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q206 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B0R0Q2 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
9 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q206 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B0R0Q2 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Embryonic camera-type eye development GO:0031076
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
9 A0A0R4IGP2 (/IGI) A0A286Y9P5 (/IGI) A0A2R8Q206 (/IGI) A0A2R8Q844 (/IGI) A0A2R8QM53 (/IGI) A0A2R8QR15 (/IGI) B0R0Q2 (/IGI) B3DK52 (/IGI) Q1LWJ4 (/IGI)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
9 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q206 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B0R0Q2 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
9 A0A0R4IGP2 (/IGI) A0A286Y9P5 (/IGI) A0A2R8Q206 (/IGI) A0A2R8Q844 (/IGI) A0A2R8QM53 (/IGI) A0A2R8QR15 (/IGI) B0R0Q2 (/IGI) B3DK52 (/IGI) Q1LWJ4 (/IGI)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
9 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q206 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B0R0Q2 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
9 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q206 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B0R0Q2 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Semicircular canal morphogenesis GO:0048752
The process in which the anatomical structures of the semicircular canals are generated and organized.
9 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q206 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B0R0Q2 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
7 A0A0R4IGP2 (/IMP) A0A286Y9P5 (/IMP) A0A2R8Q844 (/IMP) A0A2R8QM53 (/IMP) A0A2R8QR15 (/IMP) B3DK52 (/IMP) Q1LWJ4 (/IMP)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
2 A0A2R8Q206 (/IMP) B0R0Q2 (/IMP)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
1 O73798 (/IEP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 O73798 (/IDA)
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
1 O73798 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 A0A0R4IGP2 (/ISS) A0A286Y9P5 (/ISS) A0A2R8Q206 (/ISS) A0A2R8Q844 (/ISS) A0A2R8QM53 (/ISS) A0A2R8QR15 (/ISS) B0R0Q2 (/ISS) B3DK52 (/ISS) Q1LWJ4 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O73798 (/IC)