The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: lysine-specific demethylase 6A isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 Q9VL07 (/IPI)
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
1 Q9VL07 (/IMP)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
1 Q9VL07 (/IDA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
4 M9MRG4 (/IMP) M9PCJ7 (/IMP) Q76NQ3 (/IMP) Q9VL07 (/IMP)
Histone demethylation GO:0016577
The modification of histones by removal of methyl groups.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
4 M9MRG4 (/IMP) M9PCJ7 (/IMP) Q76NQ3 (/IMP) Q9VL07 (/IMP)
Sex comb development GO:0045498
The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.
4 M9MRG4 (/IMP) M9PCJ7 (/IMP) Q76NQ3 (/IMP) Q9VL07 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
4 M9MRG4 (/IMP) M9PCJ7 (/IMP) Q76NQ3 (/IMP) Q9VL07 (/IMP)
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
4 M9MRG4 (/IMP) M9PCJ7 (/IMP) Q76NQ3 (/IMP) Q9VL07 (/IMP)
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
4 M9MRG4 (/IMP) M9PCJ7 (/IMP) Q76NQ3 (/IMP) Q9VL07 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9VL07 (/IMP)
Ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072
Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis.
1 Q9VL07 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9VL07 (/IMP)
Cellular response to ecdysone GO:0071390
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
1 Q9VL07 (/IMP)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 Q9VL07 (/IMP)
Negative regulation of histone H3-K27 trimethylation GO:1902465
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation.
1 Q9VL07 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to DNA damage GO:1990248
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage.
1 Q9VL07 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
Polytene chromosome interband GO:0005705
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
MLL3/4 complex GO:0044666
A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.
4 M9MRG4 (/IDA) M9PCJ7 (/IDA) Q76NQ3 (/IDA) Q9VL07 (/IDA)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
1 Q9VL07 (/IDA)