The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cysteine Rich Protein
".
FunFam 49: Four and a half LIM domains protein 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | O35115 (/IPI) O70433 (/IPI) O70433 (/IPI) Q14192 (/IPI) Q14192 (/IPI) Q14192 (/IPI) Q9WTX7 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
4 | O35115 (/ISS) O70433 (/ISS) O70433 (/ISS) Q2KI95 (/ISS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | Q14192 (/NAS) Q14192 (/NAS) Q14192 (/NAS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
3 | Q14192 (/IPI) Q14192 (/IPI) Q14192 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | Q14192 (/IPI) Q14192 (/IPI) Q14192 (/IPI) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
3 | Q14192 (/NAS) Q14192 (/NAS) Q14192 (/NAS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q9WTX7 (/IDA) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
6 | O35115 (/IMP) O70433 (/IMP) O70433 (/IMP) Q14192 (/IMP) Q14192 (/IMP) Q14192 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | O35115 (/ISS) O70433 (/ISS) O70433 (/ISS) Q2KI95 (/ISS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | O35115 (/ISS) O70433 (/ISS) O70433 (/ISS) Q2KI95 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q14192 (/IDA) Q14192 (/IDA) Q14192 (/IDA) |
|
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
3 | Q14192 (/IMP) Q14192 (/IMP) Q14192 (/IMP) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
3 | Q14192 (/TAS) Q14192 (/TAS) Q14192 (/TAS) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
3 | Q14192 (/NAS) Q14192 (/NAS) Q14192 (/NAS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | Q14192 (/IDA) Q14192 (/IDA) Q14192 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q14192 (/NAS) Q14192 (/NAS) Q14192 (/NAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
2 | O70433 (/IEP) O70433 (/IEP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O70433 (/IDA) O70433 (/IDA) |
|
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | O70433 (/IDA) O70433 (/IDA) |
|
Atrial cardiac muscle cell development GO:0055014
The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ.
|
2 | O70433 (/IEP) O70433 (/IEP) |
|
Ventricular cardiac muscle cell development GO:0055015
The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
|
2 | O70433 (/IEP) O70433 (/IEP) |
|
Heart trabecula formation GO:0060347
The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
|
2 | O70433 (/IEP) O70433 (/IEP) |
|
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
1 | Q9WTX7 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9WTX7 (/IGI) |
|
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
1 | Q2KI95 (/ISS) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q14192 (/TAS) Q14192 (/TAS) Q14192 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q14192 (/TAS) Q14192 (/TAS) Q14192 (/TAS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | Q14192 (/HDA) Q14192 (/HDA) Q14192 (/HDA) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
3 | O35115 (/IDA) O70433 (/IDA) O70433 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O70433 (/IDA) O70433 (/IDA) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
2 | O70433 (/ISO) O70433 (/ISO) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | Q2KI95 (/ISS) |
|
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
1 | O35115 (/IDA) |