CATH Superfamily 1.50.10.20
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 5: Geranylgeranyl transferase type-1 subunit beta
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
CAAX-protein geranylgeranyltransferase activity GO:0004662
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
|
12 |
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
(2 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
12 |
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
P53609 (/ISS)
(2 more) |
|
CAAX-protein geranylgeranyltransferase activity GO:0004662
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
|
11 |
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
(1 more) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
10 | P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) P53609 (/IDA) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
3 | P53610 (/ISS) Q5EAD5 (/ISS) Q8BUY9 (/ISS) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
1 | Q8BUY9 (/ISO) |
|
CAAX-protein geranylgeranyltransferase activity GO:0004662
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
|
1 | P53610 (/IDA) |
|
CAAX-protein geranylgeranyltransferase activity GO:0004662
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
|
1 | Q8BUY9 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P53610 (/IPI) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P53610 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q8BUY9 (/ISO) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
11 |
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
(1 more) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
11 |
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
(1 more) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
3 | P53610 (/ISS) Q5EAD5 (/ISS) Q8BUY9 (/ISS) |
|
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
|
3 | M9PEL6 (/IMP) Q24172 (/IMP) Q24173 (/IMP) |
|
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
3 | M9PEL6 (/HGI) Q24172 (/HGI) Q24173 (/HGI) |
|
Blood vessel maturation GO:0001955
A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
|
2 | A0A0R4IR82 (/IMP) Q4V8Z9 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P53610 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q8BUY9 (/ISO) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | Q8BUY9 (/ISO) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P53610 (/IMP) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | Q8BUY9 (/ISO) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
1 | P53610 (/IMP) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
1 | Q8BUY9 (/ISO) |
|
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
|
1 | P53610 (/IMP) |
|
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
|
1 | Q8BUY9 (/ISO) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
11 |
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
P53609 (/IDA)
(1 more) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
11 |
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
P53609 (/TAS)
(1 more) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
2 | Q5EAD5 (/ISS) Q8BUY9 (/ISS) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
1 | Q8BUY9 (/ISO) |