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CATH Superfamily 1.50.10.130

Terpene synthase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Terpene synthase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Ent-copalyl diphosphate synthase, chloroplastic

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ent-copalyl diphosphate synthase. [EC: 5.5.1.13]
Geranylgeranyl diphosphate = ent-copalyl diphosphate.
  • Part of a bifunctional enzyme involved in the biosynthesis of kaurene.
  • See also EC 4.2.3.19.
 10 A0A2R4SUH2 A0A2R4SUH2 C7IY39 C7IY39 Q38802 Q38802 Q5MQ85 Q6ET36 Q6Z5I0 Q6Z5I0
Syn-copalyl-diphosphate synthase. [EC: 5.5.1.14]
Geranylgeranyl diphosphate = 9-alpha-copalyl diphosphate.
  • This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B.
  • Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
  • Constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighboring plants).
  • In other tissues the enzyme is up-regulated by conditions that stimulate the biosynthesis of phytoalexins.
 5 A0A0E0GXS3 A0A0E0GXS3 Q0JF02 Q6E7D7 Q6E7D7
Beta-phellandrene synthase (neryl-diphosphate-cyclizing). [EC: 4.2.3.51]
Neryl diphosphate = beta-phellandrene + diphosphate.
  • The enzyme from Solanum lycopersicum has very poor affinity with geranyl diphosphate as substrate.
  • Catalyzes the formation of the acyclic myrcene and ocimene as major products in addition to beta-phellandrene.
 4 C1K5M3 C1K5M3 R9R6F4 R9R6F4
Ent-kaurene synthase. [EC: 4.2.3.19]
Ent-copalyl diphosphate = ent-kaurene + diphosphate.
  • Part of a bifunctional enzyme involved in the biosynthesis of ent- kaurene.
  • See also EC 5.5.1.13.
 4 A0A178WDK0 A0A178WDK0 Q9SAK2 Q9SAK2
Copal-8-ol diphosphate hydratase. [EC: 4.2.1.133]
(13E)-8-alpha-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H(2)O.
  • The enzyme was characterized from the plant Cistus creticus subsp. creticus.
  • Formerly EC 3.1.7.4 and EC 5.5.1.21.
 2 E2IHE0 G3CCC0
Geranyllinalool synthase. [EC: 4.2.3.144]
Geranylgeranyl diphosphate + H(2)O = (E,E)-geranyllinalool + diphosphate.
  • The enzyme is a component of the herbivore-induced indirect defense system.
  • The product, (E,E)-geranyllinalool, is a precursor to the volatile compound 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT), which is released by many plants in response to damage.
 1 Q93YV0
(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [EC: 4.2.3.53]
(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene.
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (-)-endo-alpha-bergamotene (see EC 4.2.3.54), as well as (+)-endo-beta-bergamotene.
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation.
 1 B8XA41
Cis-abienol synthase. [EC: 4.2.3.140]
(13E)-8-alpha-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate.
  • Isolated from the plants Abies balsamea (balsam fir) and Nicotiana tabacum (tobacco).
 1 G3CCC1
(+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [EC: 4.2.3.50]
(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene.
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (see EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene (see EC 4.2.3.54).
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation.
 1 B8XA41
Miltiradiene synthase. [EC: 4.2.3.131]
(+)-copalyl diphosphate = miltiradiene + diphosphate.
  • Isolated from the plants Rosmarinus officinalis (rosemary) and Salvia miltiorrhiza.
  • The enzyme from the plant Selaginella moellendorffii is mutifunctional and also catalyzes EC 5.5.1.12.
 1 G9MAN7
(-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [EC: 4.2.3.54]
(2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene.
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene.
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation (1).
 1 B8XA41
Copalyl diphosphate synthase. [EC: 5.5.1.12]
Geranylgeranyl diphosphate = (+)-copalyl diphosphate.
  • In some plants, such as Salvia miltiorrhiza, this enzyme is monofunctional.
  • In other plants this activity is often a part of a bifunctional enzyme.
  • For example, in Selaginella moellendorffii this activity is catalyzed by a bifunctional enzyme that also catalyzes EC 4.2.3.131, while in the tree Abies grandis (grand fir) it is catalyzed by a bifunctional enzyme that also catalyzes EC 4.2.3.18.
 1 G9MAN7