The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cryptochrome circadian regulator 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 A4QN37 (/IPI) Q08BE4 (/IPI) Q49AN0 (/IPI) Q49AN0 (/IPI) Q9I917 (/IPI) Q9R194 (/IPI)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
4 Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
3 Q49AN0 (/ISS) Q49AN0 (/ISS) Q923I8 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Blue light photoreceptor activity GO:0009882
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.
2 Q49AN0 (/NAS) Q49AN0 (/NAS)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
2 Q49AN0 (/IPI) Q49AN0 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9R194 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9R194 (/ISO)
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
1 Q9R194 (/ISO)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
1 Q9R194 (/ISO)
Blue light photoreceptor activity GO:0009882
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.
1 B0WRR9 (/ISS)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 Q9R194 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q9R194 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q9R194 (/ISO)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 Q9R194 (/IPI)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 B0WRR9 (/ISS)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
1 Q9R194 (/IDA)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
27 A0A0J9YJK7 (/IDA) A0A2R8Q807 (/IDA) A0A2R8QBE8 (/IDA) A0A2R8QCA4 (/IDA) A0A2R8QLW6 (/IDA) A0A2R8QLY8 (/IDA) A0A2R8QN27 (/IDA) A0A2R8QPJ1 (/IDA) A4QN37 (/IDA) B0S7X5 (/IDA)
(17 more)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
12 A0A2R8Q807 (/IDA) A0A2R8QCA4 (/IDA) A0A2R8QLY8 (/IDA) A0A2R8QN27 (/IDA) A4QN37 (/IDA) B0S7X5 (/IDA) Q08BE4 (/IDA) Q503J5 (/IDA) Q7ZU53 (/IDA) Q9I913 (/IDA)
(2 more)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
9 A0A2R8Q807 (/IDA) A0A2R8QCA4 (/IDA) A0A2R8QLY8 (/IDA) A0A2R8QN27 (/IDA) B0S7X5 (/IDA) Q503J5 (/IDA) Q7ZU53 (/IDA) Q9I913 (/IDA) Q9I915 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
5 Q49AN0 (/ISS) Q49AN0 (/ISS) Q5IZC5 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
5 Q49AN0 (/ISS) Q49AN0 (/ISS) Q5IZC5 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
5 B0WRR9 (/ISS) Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 B0WRR9 (/ISS) Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 F1R1X1 (/IGI) Q1LWC5 (/IGI) Q7ZU27 (/IGI) Q9I916 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
4 Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
4 Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
4 Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
3 Q49AN0 (/IMP) Q49AN0 (/IMP) Q9R194 (/IMP)
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
3 A4QN37 (/IDA) Q08BE4 (/IDA) Q9I917 (/IDA)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
3 Q49AN0 (/ISS) Q49AN0 (/ISS) Q923I8 (/ISS)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
3 A4QN37 (/IEP) Q08BE4 (/IEP) Q9I917 (/IEP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
3 Q49AN0 (/ISS) Q49AN0 (/ISS) Q923I8 (/ISS)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
3 Q49AN0 (/ISS) Q49AN0 (/ISS) Q923I8 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Blue light signaling pathway GO:0009785
The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.
2 Q49AN0 (/NAS) Q49AN0 (/NAS)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Regulation of sodium-dependent phosphate transport GO:2000118
Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport.
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9R194 (/ISO)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 Q9R194 (/IPI)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q923I8 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9R194 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
1 Q9R194 (/ISO)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 Q9R194 (/IMP)
Lipid storage GO:0019915
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 Q9R194 (/IGI)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 Q9R194 (/ISO)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q9R194 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 Q9R194 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 Q9R194 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 Q9R194 (/IGI)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9R194 (/IMP)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
1 Q9R194 (/IDA)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
1 Q9R194 (/IMP)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
1 Q5IZC5 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9R194 (/IGI)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9R194 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9R194 (/ISO)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
1 Q9R194 (/IGI)
Negative regulation of glucocorticoid secretion GO:2000850
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion.
1 Q9R194 (/IGI)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 A4QN37 (/IDA) F1R1X1 (/IDA) Q08BE4 (/IDA) Q1LWC5 (/IDA) Q7ZU27 (/IDA) Q7ZU53 (/IDA) Q9I913 (/IDA) Q9I916 (/IDA) Q9I917 (/IDA) Q9R194 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A0A0D2X7Z3 (/IDA) A2I2P1 (/IDA) A2I2P1 (/IDA) Q49AN0 (/IDA) Q49AN0 (/IDA) Q5IZC5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 B0WRR9 (/ISS) Q49AN0 (/ISS) Q49AN0 (/ISS) Q8QG60 (/ISS) Q923I8 (/ISS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
5 A4QN37 (/IPI) Q08BE4 (/IPI) Q7ZU53 (/IPI) Q9I913 (/IPI) Q9I917 (/IPI)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
5 A0A0D2X7Z3 (/IDA) A2I2P1 (/IDA) A2I2P1 (/IDA) Q49AN0 (/IDA) Q49AN0 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q49AN0 (/IDA) Q49AN0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q7ZU53 (/IDA) Q9I913 (/IDA)
Nuclear envelope lumen GO:0005641
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
1 B0WRR9 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9R194 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 B0WRR9 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9R194 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9R194 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9R194 (/TAS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q9R194 (/ISO)
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
1 Q5IZC5 (/IDA)
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
1 Q5IZC5 (/IDA)