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CATH Superfamily 1.25.40.600

AmiS/UreI transporter

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: AmiS/UreI transporter

Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essential for survival in the acidic environment of the stomach.

The channel is closed at neutral pH and opens at acidic pH to allow the rapid access of urea to cytoplasmic urease PMID:23222544. UreI is a six-transmembrane segment protein that is homologous to the amiS genes of the amidase gene cluster and to UreI of Helicobacter hepaticus and Streptococcus salivarius PMID:12471160. The amiS gene encodes an 18kDa protein with a high content of hydrophobic residues. It has six transmembrane helices. AmiB and AmiS resemble two components of an ABC transporter system PMID:7642533.

This family includes UreI and proton gated urea channel as well as putative amide transporters PMID:10642549.

PMID:23222544 PMID:12471160 PMID:7642533 PMID:10642549

GO Diversity

Unique GO annotations
2 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
749 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 15
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 2
Taxonomy
Unique Species: 749