The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DOCK DHR2 domain, lobe A

DOCK (dedicator of cytokinesis) proteins are potential guanine nucleotide exchange factors that activate some small GTPases, such as Rac, by exchanging bound GDP for free GTP PMID:12432077. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis PMID:12829596. Nucleotide exchange is catalysed by a conserved catalytic DHR2 domain situated within the C-terminal region which consists of three lobes. This entry represents lobe A of DHR2 which adopts a Tetratricopeptide repeat-like fold of six antiparallel alpha-helices PMID:21613211.

PMID:12432077 PMID:12829596 PMID:21613211

GO Diversity

Unique GO annotations
153 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1277 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 7
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 5
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 13
Function
Unique EC:
Unique GO: 153
Taxonomy
Unique Species: 1277