The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
V-type ATPase, subunit H, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: V-type proton ATPase subunit H

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q9UI12 (/IPI) Q9UI12 (/IPI) Q9UI12 (/IPI) Q9UI12 (/IPI) Q9UI12 (/IPI) Q9UI12 (/IPI) Q9UI12 (/IPI)
Enzyme regulator activity GO:0030234
Binds to and modulates the activity of an enzyme.
7 Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
7 Q9UI12 (/IDA) Q9UI12 (/IDA) Q9UI12 (/IDA) Q9UI12 (/IDA) Q9UI12 (/IDA) Q9UI12 (/IDA) Q9UI12 (/IDA)
Vacuolar acidification GO:0007035
Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.
7 Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
7 Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS)
Transferrin transport GO:0033572
The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Phagosome acidification GO:0090383
Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
7 Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
3 B0R0V8 (/IMP) Q6PC35 (/IMP) Q8JHG2 (/IMP)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
3 B0R0V8 (/IMP) Q6PC35 (/IMP) Q8JHG2 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
3 B0R0V8 (/IMP) Q6PC35 (/IMP) Q8JHG2 (/IMP)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
3 B0R0V8 (/IMP) Q6PC35 (/IMP) Q8JHG2 (/IMP)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
3 O14265 (/IC) Q9V3J1 (/IC) Q9V3J1 (/IC)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 Q9V3J1 (/IMP) Q9V3J1 (/IMP)
DsRNA transport GO:0033227
The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9V3J1 (/IMP) Q9V3J1 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q8BVE3 (/ISO)
Vacuolar acidification GO:0007035
Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.
1 O14265 (/ISO)
Eye pigmentation GO:0048069
Establishment of a pattern of pigment in the eye of an organism.
1 B0R0V8 (/IMP)
Positive regulation of neural retina development GO:0061075
Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
1 B0R0V8 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
9 B3KUZ7 (/HDA) Q8TF11 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA)
Vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221
The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
7 Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS) Q9UI12 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS) Q9UI12 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
7 Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA) Q9UI12 (/HDA)
Vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221
The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
2 Q9V3J1 (/ISS) Q9V3J1 (/ISS)
Plasma membrane proton-transporting V-type ATPase complex GO:0033181
A proton-transporting two-sector ATPase complex found in the plasma membrane.
2 Q9V3J1 (/IMP) Q9V3J1 (/IMP)
Vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221
The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
1 O14265 (/ISO)