The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Protein prenylyltransferase
".
FunFam 16: Geranylgeranyltransferase type II alpha subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
5 | O93829 (/ISS) Q00618 (/ISS) Q00618 (/ISS) Q00618 (/ISS) Q00618 (/ISS) |
|
Rab geranylgeranyltransferase activity GO:0004663
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
|
4 | Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q00618 (/IPI) Q00618 (/IPI) Q00618 (/IPI) Q00618 (/IPI) |
|
Rab geranylgeranyltransferase activity GO:0004663
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
|
1 | O93829 (/ISS) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
|
4 | Q00618 (/IMP) Q00618 (/IMP) Q00618 (/IMP) Q00618 (/IMP) |
|
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
|
4 | Q00618 (/IMP) Q00618 (/IMP) Q00618 (/IMP) Q00618 (/IMP) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
4 | Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
4 | Q00618 (/IMP) Q00618 (/IMP) Q00618 (/IMP) Q00618 (/IMP) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | O93829 (/ISS) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
4 | Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | Q00618 (/HDA) Q00618 (/HDA) Q00618 (/HDA) Q00618 (/HDA) |
|
Rab-protein geranylgeranyltransferase complex GO:0005968
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
|
4 | Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) Q00618 (/IDA) |
|
Rab-protein geranylgeranyltransferase complex GO:0005968
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
|
4 | Q00618 (/IPI) Q00618 (/IPI) Q00618 (/IPI) Q00618 (/IPI) |
|
Rab-protein geranylgeranyltransferase complex GO:0005968
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
|
1 | O93829 (/ISS) |