The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
IP3 receptor type 1 binding core, RIH domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: ryanodine receptor isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 50 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
20 A0A0R4IA72 (/IPI) A6P4B8 (/IPI) B0LPN4 (/IPI) B7WN66 (/IPI) E9PZQ0 (/IPI) E9Q401 (/IPI) F1LMY4 (/IPI) F1NLZ9 (/IPI) F1PEE8 (/IPI) F1QEX9 (/IPI)
(10 more)
Ryanodine-sensitive calcium-release channel activity GO:0005219
Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
10 B0LPN4 (/IDA) E9Q401 (/IDA) F1LMY4 (/IDA) F1LPJ2 (/IDA) F1M7A1 (/IDA) F1PEE8 (/IDA) P11716 (/IDA) P21817 (/IDA) Q92736 (/IDA) Q9TS33 (/IDA)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
7 B0LPN4 (/ISS) F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS) P30957 (/ISS) Q92736 (/ISS)
Ryanodine-sensitive calcium-release channel activity GO:0005219
Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
6 A2AGL3 (/ISS) E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS) Q15413 (/ISS)
Ryanodine-sensitive calcium-release channel activity GO:0005219
Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
5 A6P4B8 (/IMP) B0LPN4 (/IMP) E9PZQ0 (/IMP) F1QEX9 (/IMP) P21817 (/IMP)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
4 F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
4 B0LPN4 (/ISS) P21817 (/ISS) P30957 (/ISS) Q92736 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 E9Q401 (/IPI) P11716 (/IPI) Q92736 (/IPI) Q9TS33 (/IPI)
Calcium-induced calcium release activity GO:0048763
Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration.
4 B0LPN4 (/IDA) F1LPJ2 (/IDA) F1M7A1 (/IDA) Q92736 (/IDA)
Ryanodine-sensitive calcium-release channel activity GO:0005219
Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
3 A2AGL3 (/ISO) E9PZQ0 (/ISO) E9Q401 (/ISO)
Ryanodine-sensitive calcium-release channel activity GO:0005219
Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
3 P21817 (/TAS) Q15413 (/TAS) Q24498 (/TAS)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 E9Q401 (/IDA) P11716 (/IDA) Q92736 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
3 F1NLZ9 (/IDA) P11716 (/IDA) P30957 (/IDA)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
3 B0LPN4 (/ISS) P30957 (/ISS) Q92736 (/ISS)
Toxic substance binding GO:0015643
Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems.
3 A0A060WZC7 (/IDA) G1U7D3 (/IDA) P11716 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
3 E9PZQ0 (/IPI) E9Q401 (/IPI) Q92736 (/IPI)
Calcium-induced calcium release activity GO:0048763
Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration.
3 A2AGL3 (/ISO) E9PZQ0 (/ISO) E9Q401 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 P11716 (/IPI) Q92736 (/IPI)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
2 E9Q401 (/IDA) Q92736 (/IDA)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
2 P11716 (/IMP) Q15413 (/IMP)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
2 A2AGL3 (/ISO) E9Q401 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
2 F1PEE8 (/IPI) P11716 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 E9PZQ0 (/IPI)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 E9PZQ0 (/IDA)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 E9Q401 (/IDA)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 E9PZQ0 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P11716 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q92736 (/IMP)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 E9Q401 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P11716 (/IDA)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
1 P21817 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 E9Q401 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 E9Q401 (/IPI)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
1 Q92736 (/IDA)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
1 E9Q401 (/ISO)
Protein kinase A regulatory subunit binding GO:0034237
Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
1 Q92736 (/IDA)
Protein kinase A regulatory subunit binding GO:0034237
Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
1 E9Q401 (/ISO)
ATP-gated ion channel activity GO:0035381
Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.
1 P11716 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 E9Q401 (/ISO)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 E9Q401 (/IMP)
Suramin binding GO:0043924
Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.
1 Q92736 (/IMP)
Suramin binding GO:0043924
Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.
1 E9Q401 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q92736 (/ISS)
Calcium-induced calcium release activity GO:0048763
Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration.
1 P21817 (/IMP)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 B0LPN4 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 E9Q401 (/ISO)
Organic cyclic compound binding GO:0097159
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
1 E9Q401 (/IPI)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
1 P11716 (/IPI)

There are 151 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
10 A2AGL3 (/ISS) B0LPN4 (/ISS) E9PZQ0 (/ISS) F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS) P30957 (/ISS) Q15413 (/ISS) Q92736 (/ISS)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
6 A0A060WZC7 (/IMP) E9PZQ0 (/IMP) E9Q401 (/IMP) G1U7D3 (/IMP) P11716 (/IMP) Q92736 (/IMP)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
6 E9PZQ0 (/ISS) F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS) Q92736 (/ISS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
6 A2AGL3 (/ISS) E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS) Q15413 (/ISS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
6 A2AGL3 (/ISS) E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS) Q15413 (/ISS)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
5 A0A0R4IA72 (/IMP) A6P4B8 (/IMP) F1QCK4 (/IMP) F1QEX9 (/IMP) Q5RGQ4 (/IMP)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
4 F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 E9PZQ0 (/IDA) E9Q401 (/IDA) F1LMY4 (/IDA) Q92736 (/IDA)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
4 F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS)
Protein localization to organelle GO:0033365
A process in which a protein is transported to, or maintained in, a location within an organelle.
4 B7WN66 (/IMP) I2HAA6 (/IMP) I2HAA7 (/IMP) Q94279 (/IMP)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
4 B7WN66 (/IMP) I2HAA6 (/IMP) I2HAA7 (/IMP) Q94279 (/IMP)
Positive regulation of programmed cell death GO:0043068
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
4 B7WN66 (/IGI) I2HAA6 (/IGI) I2HAA7 (/IGI) Q94279 (/IGI)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
4 F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS)
Ossification involved in bone maturation GO:0043931
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
4 F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
4 F1LMY4 (/ISS) P11716 (/ISS) P16960 (/ISS) P21817 (/ISS)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
4 E9Q401 (/IDA) P11716 (/IDA) Q92736 (/IDA) Q9TS33 (/IDA)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
3 B0LPN4 (/ISS) P30957 (/ISS) Q92736 (/ISS)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 A2AGL3 (/ISO) E9PZQ0 (/ISO) E9Q401 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 B0LPN4 (/ISS) P21817 (/ISS) P30957 (/ISS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
3 B0LPN4 (/ISS) P30957 (/ISS) Q92736 (/ISS)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
3 A0A0R4IA72 (/IGI) F1QCK4 (/IGI) Q5RGQ4 (/IGI)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
3 E9Q401 (/IDA) F1LMY4 (/IDA) F1PEE8 (/IDA)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
3 B0LPN4 (/ISS) P30957 (/ISS) Q92736 (/ISS)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
3 E9Q401 (/IDA) F1LMY4 (/IDA) Q92736 (/IDA)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
3 P21817 (/TAS) Q15413 (/TAS) Q92736 (/TAS)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
3 F1LMY4 (/IDA) P11716 (/IDA) Q92736 (/IDA)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
3 B0LPN4 (/IDA) F1LPJ2 (/IDA) F1M7A1 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 F1PEE8 (/IDA) P11716 (/IDA) Q9TS33 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 A2AGL3 (/ISS) P16960 (/ISS) Q15413 (/ISS)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
3 P21817 (/TAS) Q15413 (/TAS) Q92736 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 E9Q401 (/IDA) P21817 (/IDA)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
2 E9Q401 (/IMP) Q92736 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 E9Q401 (/IMP) Q15413 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P21817 (/TAS) Q24498 (/TAS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 A2AGL3 (/IMP) E9Q401 (/IMP)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
2 E9PZQ0 (/IMP) Q24498 (/IMP)
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
2 A6P4B8 (/IMP) F1QEX9 (/IMP)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Fast-twitch skeletal muscle fiber contraction GO:0031443
A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.
2 A6P4B8 (/IMP) F1QEX9 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 A6P4B8 (/IMP) F1QEX9 (/IMP)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
2 E9PZQ0 (/IMP) P21817 (/IMP)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
2 P21817 (/ISS) Q92736 (/ISS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 P11716 (/IDA) Q9TS33 (/IDA)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
2 P21817 (/ISS) Q92736 (/ISS)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
2 A2AGL3 (/ISO) E9Q401 (/ISO)
Sarcoplasmic reticulum calcium ion transport GO:0070296
The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
2 B0LPN4 (/IMP) E9Q401 (/IMP)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 P11716 (/IDA) Q9TS33 (/IDA)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
2 A2AGL3 (/ISS) Q15413 (/ISS)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
2 E9PZQ0 (/IMP) P21817 (/IMP)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
2 F1LMY4 (/IDA) Q9TS33 (/IDA)
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
2 A2AGL3 (/ISS) Q15413 (/ISS)
Type B pancreatic cell apoptotic process GO:0097050
Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.
2 E9Q401 (/IMP) Q92736 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 E9PZQ0 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q92736 (/ISS)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
1 E9Q401 (/ISO)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
1 E9Q401 (/IMP)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
1 E9PZQ0 (/IMP)
Left ventricular cardiac muscle tissue morphogenesis GO:0003220
The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.
1 E9Q401 (/IMP)
Left ventricular cardiac muscle tissue morphogenesis GO:0003220
The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.
1 Q92736 (/ISS)
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
1 E9Q401 (/IMP)
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
1 Q92736 (/ISS)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
1 Q92736 (/IDA)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
1 E9Q401 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 E9Q401 (/IPI)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q9TS33 (/TAS)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 E9PZQ0 (/IDA)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 Q9TS33 (/NAS)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 P21817 (/TAS)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 E9PZQ0 (/TAS)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 A2AGL3 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 B0LPN4 (/IEP)
Positive regulation of heart rate GO:0010460
Any process that activates or increases the frequency or rate of heart contraction.
1 E9Q401 (/IMP)
Positive regulation of heart rate GO:0010460
Any process that activates or increases the frequency or rate of heart contraction.
1 Q92736 (/ISS)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881
Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
1 Q92736 (/IC)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881
Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
1 E9Q401 (/IGI)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881
Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
1 Q92736 (/ISS)
Regulation of cardiac muscle contraction by calcium ion signaling GO:0010882
Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
1 Q92736 (/IMP)
Regulation of cardiac muscle contraction by calcium ion signaling GO:0010882
Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
1 E9Q401 (/ISO)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 Q92736 (/IMP)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 E9Q401 (/ISO)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 E9Q401 (/IMP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 E9Q401 (/IDA)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
1 P21817 (/ISS)
Response to magnesium ion GO:0032026
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 B0LPN4 (/IDA)
Response to magnesium ion GO:0032026
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 E9Q401 (/ISO)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 F1LMY4 (/IEP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 B0LPN4 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 E9Q401 (/ISO)
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
1 Q24498 (/IMP)
Calcium-mediated signaling using intracellular calcium source GO:0035584
A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.
1 Q92736 (/IDA)
Calcium-mediated signaling using intracellular calcium source GO:0035584
A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.
1 E9Q401 (/ISO)
Response to muscle stretch GO:0035994
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
1 Q92736 (/IMP)
Response to muscle stretch GO:0035994
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
1 E9Q401 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 B0LPN4 (/IEP)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
1 E9PZQ0 (/IMP)
Ossification involved in bone maturation GO:0043931
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
1 E9PZQ0 (/IMP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
1 E9PZQ0 (/IMP)
Positive regulation of sequestering of calcium ion GO:0051284
Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
1 Q92736 (/IDA)
Positive regulation of sequestering of calcium ion GO:0051284
Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
1 E9Q401 (/ISO)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 F1LMY4 (/IDA)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 B0LPN4 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 B0LPN4 (/IDA)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 E9Q401 (/ISO)
Response to redox state GO:0051775
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
1 Q92736 (/IDA)
Response to redox state GO:0051775
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
1 E9Q401 (/ISO)
Regulation of cardiac muscle contraction GO:0055117
Any process that modulates the frequency, rate or extent of cardiac muscle contraction.
1 Q92736 (/IMP)
Regulation of cardiac muscle contraction GO:0055117
Any process that modulates the frequency, rate or extent of cardiac muscle contraction.
1 E9Q401 (/ISO)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 Q24498 (/IMP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 Q92736 (/IMP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 E9Q401 (/ISO)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
1 E9Q401 (/IDA)
Cytosolic calcium ion transport GO:0060401
The directed movement of calcium ions (Ca2+) into, out of or within the cytosol.
1 E9Q401 (/IMP)
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
1 Q92736 (/IDA)
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
1 E9Q401 (/ISO)
Sarcoplasmic reticulum calcium ion transport GO:0070296
The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.
1 F1LMY4 (/IDA)
Sarcoplasmic reticulum calcium ion transport GO:0070296
The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.
1 B0LPN4 (/IMP)
Sarcoplasmic reticulum calcium ion transport GO:0070296
The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.
1 Q92736 (/TAS)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 E9Q401 (/ISO)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 Q9TS33 (/IDA)
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
1 E9PZQ0 (/ISO)
Manganese ion transmembrane transport GO:0071421
A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 B0LPN4 (/IMP)
Manganese ion transmembrane transport GO:0071421
A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 E9Q401 (/ISO)
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
1 E9Q401 (/IMP)
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
1 Q92736 (/ISS)
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
1 Q92736 (/TAS)
Response to anesthetic GO:0072347
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.
1 Q24498 (/IMP)
Establishment of protein localization to endoplasmic reticulum GO:0072599
The directed movement of a protein to a specific location in the endoplasmic reticulum.
1 Q92736 (/IDA)
Establishment of protein localization to endoplasmic reticulum GO:0072599
The directed movement of a protein to a specific location in the endoplasmic reticulum.
1 E9Q401 (/ISO)
Ventricular cardiac muscle cell action potential GO:0086005
An action potential that occurs in a ventricular cardiac muscle cell.
1 E9Q401 (/IMP)
Ventricular cardiac muscle cell action potential GO:0086005
An action potential that occurs in a ventricular cardiac muscle cell.
1 Q92736 (/ISS)
Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029
Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.
1 E9Q401 (/IMP)
Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029
Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.
1 Q92736 (/ISS)
Cell communication by electrical coupling involved in cardiac conduction GO:0086064
The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.
1 Q92736 (/IC)
Type B pancreatic cell apoptotic process GO:0097050
Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.
1 E9Q401 (/ISO)
Positive regulation of the force of heart contraction GO:0098735
Any process that increases the force of heart muscle contraction.
1 Q92736 (/IMP)
Positive regulation of the force of heart contraction GO:0098735
Any process that increases the force of heart muscle contraction.
1 E9Q401 (/ISO)
Regulation of AV node cell action potential GO:0098904
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 Q92736 (/IMP)
Regulation of AV node cell action potential GO:0098904
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 E9Q401 (/ISO)
Regulation of SA node cell action potential GO:0098907
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 Q92736 (/IMP)
Regulation of SA node cell action potential GO:0098907
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 E9Q401 (/ISO)
Regulation of atrial cardiac muscle cell action potential GO:0098910
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 Q92736 (/IMP)
Regulation of atrial cardiac muscle cell action potential GO:0098910
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 E9Q401 (/ISO)
Regulation of ventricular cardiac muscle cell action potential GO:0098911
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 Q92736 (/IMP)
Regulation of ventricular cardiac muscle cell action potential GO:0098911
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 E9Q401 (/ISO)
Positive regulation of ATPase-coupled calcium transmembrane transporter activity GO:1901896
Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.
1 Q92736 (/IDA)
Positive regulation of ATPase-coupled calcium transmembrane transporter activity GO:1901896
Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.
1 E9Q401 (/ISO)

There are 60 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
9 B0LPN4 (/IDA) E9PZQ0 (/IDA) E9Q401 (/IDA) F1LMY4 (/IDA) I2HAA6 (/IDA) P11716 (/IDA) P30957 (/IDA) Q92736 (/IDA) Q9TS33 (/IDA)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
8 A2AGL3 (/IDA) B0LPN4 (/IDA) E9PZQ0 (/IDA) E9Q401 (/IDA) F1LMY4 (/IDA) P11716 (/IDA) P21817 (/IDA) Q9TS33 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 A0A060WZC7 (/IDA) E9PZQ0 (/IDA) E9Q401 (/IDA) G1U7D3 (/IDA) P11716 (/IDA) Q92736 (/IDA)
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
5 B7WN66 (/IDA) I2HAA6 (/IDA) I2HAA7 (/IDA) P21817 (/IDA) Q94279 (/IDA)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
5 P11716 (/ISS) P16960 (/ISS) P21817 (/ISS) Q15413 (/ISS) Q92736 (/ISS)
Terminal cisterna GO:0014802
The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release.
4 A0A060WZC7 (/IDA) F1LMY4 (/IDA) G1U7D3 (/IDA) P11716 (/IDA)
Integral component of organelle membrane GO:0031301
The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS)
Ryanodine receptor complex GO:1990425
A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom.
4 E9PZQ0 (/ISS) F1LMY4 (/ISS) P16960 (/ISS) P21817 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 B0LPN4 (/IDA) F1LPJ2 (/IDA) F1M7A1 (/IDA)
Terminal cisterna GO:0014802
The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release.
3 E9PZQ0 (/ISS) P16960 (/ISS) P21817 (/ISS)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
3 P16960 (/ISS) P21817 (/ISS) Q15413 (/ISS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
3 B0LPN4 (/IDA) E9Q401 (/IDA) Q92736 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 B0LPN4 (/IDA) E9PZQ0 (/IDA) Q92736 (/IDA)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
3 P21817 (/TAS) Q15413 (/TAS) Q92736 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 B0LPN4 (/IDA) P21817 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 A2AGL3 (/ISO) E9Q401 (/ISO)
Smooth endoplasmic reticulum GO:0005790
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
2 E9PZQ0 (/IDA) E9Q401 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 B0LPN4 (/IDA) P21817 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Junctional sarcoplasmic reticulum membrane GO:0014701
The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane.
2 P21817 (/TAS) Q92736 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P11716 (/IDA) Q9TS33 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 A2AGL3 (/ISS) Q15413 (/ISS)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Junctional membrane complex GO:0030314
Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).
2 A2AGL3 (/IDA) E9PZQ0 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 B0LPN4 (/IDA) F1LMY4 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
2 E9Q401 (/IDA) Q92736 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 B0LPN4 (/IDA) F1LMY4 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 E9PZQ0 (/ISO) E9Q401 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 F1NLZ9 (/IDA) P30957 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 F1LPJ2 (/IDA) F1M7A1 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 B0LPN4 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 E9Q401 (/ISO)
Smooth endoplasmic reticulum GO:0005790
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
1 P21817 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q92736 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P21817 (/TAS)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
1 F1PEE8 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 P21817 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 E9PZQ0 (/ISO)
Terminal cisterna GO:0014802
The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release.
1 E9PZQ0 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 E9Q401 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 E9Q401 (/IC)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q24498 (/NAS)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 E9Q401 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 E9Q401 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q92736 (/ISS)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 E9PZQ0 (/IDA)
Integral component of organelle membrane GO:0031301
The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P11716 (/IDA)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
1 B0LPN4 (/IDA)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
1 E9Q401 (/ISO)
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
1 E9PZQ0 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 E9Q401 (/ISO)
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
1 E9Q401 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 B0LPN4 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 E9Q401 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 A2AGL3 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P21817 (/HDA)
Ryanodine receptor complex GO:1990425
A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom.
1 P11716 (/IDA)