The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 49: Engulfment and cell motility 1 (Ced-12 homolog)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 Q8BPU7 (/IPI) Q8BPU7 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI)
(5 more)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
8 Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
5 Q96JJ3 (/IPI) Q96JJ3 (/IPI) Q96JJ3 (/IPI) Q96JJ3 (/IPI) Q96JJ3 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 Q8BHL5 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
13 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q96JJ3 (/TAS) Q96JJ3 (/TAS)
(3 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
13 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q96JJ3 (/TAS) Q96JJ3 (/TAS)
(3 more)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
8 Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
8 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
5 Q96JJ3 (/IMP) Q96JJ3 (/IMP) Q96JJ3 (/IMP) Q96JJ3 (/IMP) Q96JJ3 (/IMP)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
3 A0A0R4IHP8 (/IMP) A0A0R4IJC9 (/IMP) Q6NV39 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
3 A0A0R4IHP8 (/IMP) A0A0R4IJC9 (/IMP) Q6NV39 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
3 A0A0R4IHP8 (/IGI) A0A0R4IJC9 (/IGI) Q6NV39 (/IGI)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
3 A4FUD6 (/ISS) Q5RCC1 (/ISS) Q8BHL5 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 Q8BPU7 (/IDA) Q8BPU7 (/IDA)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Actin filament-based process GO:0030029
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
2 Q8BPU7 (/IDA) Q8BPU7 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q8BHL5 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q96JJ3 (/TAS) Q96JJ3 (/TAS)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 Q5JVZ4 (/IDA) Q5JVZ4 (/IDA) Q5JVZ4 (/IDA) Q5JVZ5 (/IDA) Q5JVZ5 (/IDA) Q5JVZ5 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA)
(1 more)
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
10 Q8BPU7 (/IDA) Q8BPU7 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A4FUD6 (/ISS) Q5RCC1 (/ISS) Q8BHL5 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 A4FUD6 (/ISS) Q5RCC1 (/ISS) Q8BHL5 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BHL5 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8BHL5 (/ISO)