CATH Superfamily 1.20.930.10
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
".
FunFam 5: PC4 and SFRS1-interacting protein-like isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
11 |
A1YAF7 (/ISS)
B8Y8S3 (/ISS)
D2H2Y2 (/ISS)
E2REJ7 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
Q5XXA9 (/ISS)
Q66T72 (/ISS)
Q8MJG1 (/ISS)
(1 more) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
7 | A1YAF7 (/ISS) B8Y8S3 (/ISS) D2H2Y2 (/ISS) E2REJ7 (/ISS) Q5XXA9 (/ISS) Q66T72 (/ISS) Q8MJG1 (/ISS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
7 | A1YAF7 (/ISS) B8Y8S3 (/ISS) D2H2Y2 (/ISS) E2REJ7 (/ISS) Q5XXA9 (/ISS) Q66T72 (/ISS) Q8MJG1 (/ISS) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
7 | A1YAF7 (/ISS) B8Y8S3 (/ISS) D2H2Y2 (/ISS) E2REJ7 (/ISS) Q5XXA9 (/ISS) Q66T72 (/ISS) Q8MJG1 (/ISS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
3 | O75475 (/HDA) O75475 (/HDA) O75475 (/HDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | O75475 (/IPI) O75475 (/IPI) O75475 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q99JF8 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q99JF8 (/ISO) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
1 | Q99JF8 (/ISO) |
|
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
1 | Q812D1 (/IDA) |
|
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
1 | Q99JF8 (/ISO) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
11 |
A1YAF7 (/ISS)
B8Y8S3 (/ISS)
D2H2Y2 (/ISS)
E2REJ7 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
Q5XXA9 (/ISS)
Q66T72 (/ISS)
Q812D1 (/ISS)
(1 more) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
11 |
A1YAF7 (/ISS)
B8Y8S3 (/ISS)
D2H2Y2 (/ISS)
E2REJ7 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
Q5XXA9 (/ISS)
Q66T72 (/ISS)
Q812D1 (/ISS)
(1 more) |
|
MRNA 5'-splice site recognition GO:0000395
Recognition of the intron 5'-splice site by components of the assembling spliceosome.
|
9 | A1YAF7 (/ISS) B8Y8S3 (/ISS) D2H2Y2 (/ISS) E2REJ7 (/ISS) Q5XXA9 (/ISS) Q66T72 (/ISS) Q812D1 (/ISS) Q8MJG1 (/ISS) Q99JF8 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | A1YAF7 (/ISS) B8Y8S3 (/ISS) D2H2Y2 (/ISS) E2REJ7 (/ISS) Q5XXA9 (/ISS) Q66T72 (/ISS) Q8MJG1 (/ISS) |
|
MRNA 5'-splice site recognition GO:0000395
Recognition of the intron 5'-splice site by components of the assembling spliceosome.
|
3 | O75475 (/IDA) O75475 (/IDA) O75475 (/IDA) |
|
Nuclear transport GO:0051169
The directed movement of substances into, out of, or within the nucleus.
|
3 | O75475 (/TAS) O75475 (/TAS) O75475 (/TAS) |
|
Establishment of integrated proviral latency GO:0075713
A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
|
3 | O75475 (/TAS) O75475 (/TAS) O75475 (/TAS) |
|
MRNA 5'-splice site recognition GO:0000395
Recognition of the intron 5'-splice site by components of the assembling spliceosome.
|
1 | Q99JF8 (/ISO) |
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q99JF8 (/IDA) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | Q99JF8 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q99JF8 (/ISO) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
|
11 |
A1YAF7 (/ISS)
B8Y8S3 (/ISS)
D2H2Y2 (/ISS)
E2REJ7 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
O75475 (/ISS)
Q5XXA9 (/ISS)
Q66T72 (/ISS)
Q8MJG1 (/ISS)
(1 more) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
8 | A1YAF7 (/ISS) B8Y8S3 (/ISS) D2H2Y2 (/ISS) E2REJ7 (/ISS) Q5XXA9 (/ISS) Q66T72 (/ISS) Q8MJG1 (/ISS) Q99JF8 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | O75475 (/IDA) O75475 (/IDA) O75475 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | O75475 (/TAS) O75475 (/TAS) O75475 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O75475 (/TAS) O75475 (/TAS) O75475 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q5XXA9 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q99JF8 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q99JF8 (/ISO) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
1 | Q812D1 (/IDA) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
1 | Q99JF8 (/ISO) |
|
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
1 | Q99JF8 (/ISO) |
|
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
|
1 | Q812D1 (/IDA) |
|
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
|
1 | Q99JF8 (/ISO) |