The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Bromodomain-like
".
FunFam 14: Histone acetyltransferase KAT2B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 43 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | D4ACX5 (/IPI) Q92830 (/IPI) Q92831 (/IPI) Q9JHD1 (/IPI) Q9JHD1 (/IPI) Q9JHD2 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
5 | D4ACX5 (/IDA) Q92830 (/IDA) Q9JHD1 (/IDA) Q9JHD1 (/IDA) Q9JHD2 (/IDA) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
5 | Q92830 (/IDA) Q92831 (/IDA) Q9JHD1 (/IDA) Q9JHD1 (/IDA) Q9JHD2 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
4 | Q92830 (/IDA) Q92831 (/IDA) Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0004468
Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
|
3 | Q92831 (/IDA) Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
3 | Q92830 (/IPI) Q92831 (/IPI) Q9JHD2 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Peptide-lysine-N-acetyltransferase activity GO:0061733
Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | A0A0R4IXF6 (/ISS) Q92831 (/ISS) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | A0A0R4IXF6 (/ISS) Q9JHD2 (/ISS) |
|
Lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0004468
Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861
Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
H3 histone acetyltransferase activity GO:0010484
Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.
|
2 | Q92830 (/IDA) Q9JHD2 (/IDA) |
|
Acetyltransferase activity GO:0016407
Catalysis of the transfer of an acetyl group to an acceptor molecule.
|
2 | Q9JHD1 (/EXP) Q9JHD1 (/EXP) |
|
Acetyltransferase activity GO:0016407
Catalysis of the transfer of an acetyl group to an acceptor molecule.
|
2 | Q92831 (/IDA) Q9JHD2 (/IDA) |
|
Acetyltransferase activity GO:0016407
Catalysis of the transfer of an acetyl group to an acceptor molecule.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | Q9JHD1 (/IPI) Q9JHD1 (/IPI) |
|
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q92830 (/IPI) Q92831 (/IPI) |
|
Peptide-lysine-N-acetyltransferase activity GO:0061733
Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.
|
2 | Q92830 (/IDA) Q92831 (/IDA) |
|
Peptide-lysine-N-acetyltransferase activity GO:0061733
Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.
|
2 | A0A0R4IXF6 (/ISS) Q1LUC3 (/ISS) |
|
Histone succinyltransferase activity GO:0106078
Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone.
|
2 | A0A0R4IXF6 (/ISS) Q9JHD2 (/ISS) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
1 | Q92831 (/IPI) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
1 | Q92831 (/EXP) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
1 | Q92831 (/IMP) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
1 | A0A0R4IXF6 (/ISS) |
|
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
|
1 | Q92830 (/TAS) |
|
Lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0004468
Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
|
1 | Q92831 (/ISS) |
|
Cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861
Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
|
1 | Q92831 (/ISS) |
|
N-acetyltransferase activity GO:0008080
Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
|
1 | Q9JHD2 (/IDA) |
|
H3 histone acetyltransferase activity GO:0010484
Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.
|
1 | Q9JHD2 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q92831 (/ISS) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | D4ACX5 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | Q9JHD2 (/ISO) |
|
Histone acetyltransferase activity (H4-K12 specific) GO:0043997
Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12).
|
1 | Q9JHD2 (/IDA) |
|
Histone succinyltransferase activity GO:0106078
Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone.
|
1 | Q92830 (/IDA) |
|
Histone succinyltransferase activity GO:0106078
Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone.
|
1 | Q9JHD2 (/ISO) |
There are 101 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
5 | Q92830 (/ISS) Q92831 (/ISS) Q9JHD1 (/ISS) Q9JHD1 (/ISS) Q9JHD2 (/ISS) |
|
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
5 | Q92830 (/ISS) Q92831 (/ISS) Q9JHD1 (/ISS) Q9JHD1 (/ISS) Q9JHD2 (/ISS) |
|
Protein acetylation GO:0006473
The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
3 | Q92831 (/TAS) Q9JHD1 (/TAS) Q9JHD1 (/TAS) |
|
Internal peptidyl-lysine acetylation GO:0018393
The addition of an acetyl group to a non-terminal lysine residue in a protein.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter GO:0035948
Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q9JHD1 (/IGI) Q9JHD1 (/IGI) Q9JHD2 (/IGI) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
3 | Q92830 (/IDA) Q92831 (/IDA) Q9JHD2 (/IDA) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Negative regulation of centriole replication GO:0046600
Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Negative regulation of centriole replication GO:0046600
Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.
|
3 | Q1LUC3 (/ISS) Q9JHD1 (/ISS) Q9JHD1 (/ISS) |
|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | A0A0R4IXF6 (/ISS) Q92830 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
2 | Q9JHD1 (/ISS) Q9JHD1 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
2 | Q92830 (/TAS) Q92831 (/TAS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q9JHD1 (/TAS) Q9JHD1 (/TAS) |
|
Protein acetylation GO:0006473
The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | A0A0R4IXF6 (/IMP) Q1LUC3 (/IMP) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
2 | A0A0R4IXF6 (/ISS) Q92830 (/ISS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Regulation of protein ADP-ribosylation GO:0010835
Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
2 | Q92830 (/TAS) Q92831 (/TAS) |
|
N-terminal peptidyl-lysine acetylation GO:0018076
The acetylation of the N-terminal lysine of proteins.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Internal peptidyl-lysine acetylation GO:0018393
The addition of an acetyl group to a non-terminal lysine residue in a protein.
|
2 | Q92830 (/IDA) Q92831 (/IDA) |
|
Internal peptidyl-lysine acetylation GO:0018393
The addition of an acetyl group to a non-terminal lysine residue in a protein.
|
2 | Q9JHD1 (/IMP) Q9JHD1 (/IMP) |
|
Internal peptidyl-lysine acetylation GO:0018393
The addition of an acetyl group to a non-terminal lysine residue in a protein.
|
2 | A0A0R4IXF6 (/ISS) Q1LUC3 (/ISS) |
|
Peptidyl-lysine acetylation GO:0018394
The acetylation of peptidyl-lysine.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Histone H3-K9 acetylation GO:0043970
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone.
|
2 | Q9JHD1 (/IGI) Q9JHD1 (/IGI) |
|
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
|
2 | A0A0R4IXF6 (/ISS) Q92830 (/ISS) |
|
Negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736
Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Positive regulation of gene expression, epigenetic GO:0045815
Any epigenetic process that activates or increases the rate of gene expression.
|
2 | Q92830 (/TAS) Q92831 (/TAS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q92830 (/IDA) Q92831 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q9JHD1 (/IGI) Q9JHD1 (/IGI) |
|
Negative regulation of centriole replication GO:0046600
Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.
|
2 | Q92830 (/IDA) Q92831 (/IDA) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
2 | A0A0R4IXF6 (/ISS) Q92830 (/ISS) |
|
Regulation of T cell activation GO:0050863
Any process that modulates the frequency, rate or extent of T cell activation.
|
2 | A0A0R4IXF6 (/ISS) Q92830 (/ISS) |
|
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
2 | A0A0R4IXF6 (/IMP) Q1LUC3 (/IMP) |
|
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
|
2 | A0A0R4IXF6 (/IMP) Q1LUC3 (/IMP) |
|
Positive regulation of histone H3-K14 acetylation GO:0071442
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Histone succinylation GO:0106077
The modification of a histone by the addition of an succinyl group.
|
2 | A0A0R4IXF6 (/ISS) Q9JHD2 (/ISS) |
|
Positive regulation of histone H3-K9 acetylation GO:2000617
Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | Q9JHD2 (/IMP) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q9JHD2 (/IGI) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q9JHD2 (/IMP) |
|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | Q9JHD2 (/IMP) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | Q9JHD2 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q92831 (/IDA) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q92831 (/NAS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q92830 (/TAS) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
1 | Q92831 (/TAS) |
|
Protein acetylation GO:0006473
The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
1 | Q92831 (/IDA) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
1 | Q92831 (/TAS) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q92831 (/TAS) |
|
Positive regulation of transcription of Notch receptor target GO:0007221
The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.
|
1 | Q92831 (/TAS) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | Q9JHD2 (/IMP) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | Q9JHD2 (/IMP) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | Q9JHD2 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q92831 (/IDA) |
|
Regulation of protein ADP-ribosylation GO:0010835
Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q92831 (/IDA) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | D4ACX5 (/IEP) |
|
Histone deubiquitination GO:0016578
The modification of histones by removal of ubiquitin groups.
|
1 | Q92830 (/IDA) |
|
Histone deubiquitination GO:0016578
The modification of histones by removal of ubiquitin groups.
|
1 | Q9JHD2 (/ISO) |
|
N-terminal peptidyl-lysine acetylation GO:0018076
The acetylation of the N-terminal lysine of proteins.
|
1 | Q92831 (/IDA) |
|
Peptidyl-lysine acetylation GO:0018394
The acetylation of peptidyl-lysine.
|
1 | Q92831 (/IDA) |
|
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
|
1 | Q9JHD2 (/IMP) |
|
Metencephalon development GO:0022037
The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.
|
1 | Q9JHD2 (/IMP) |
|
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
1 | Q9JHD2 (/IMP) |
|
Positive regulation of cell projection organization GO:0031346
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
|
1 | D4ACX5 (/IMP) |
|
Positive regulation of cell projection organization GO:0031346
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
|
1 | Q9JHD2 (/ISO) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
1 | Q92830 (/IMP) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
1 | Q9JHD2 (/ISO) |
|
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | D4ACX5 (/IEP) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q92831 (/IDA) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
1 | D4ACX5 (/IMP) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
1 | Q9JHD2 (/ISO) |
|
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | Q9JHD2 (/IMP) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
1 | A0A0R4IXF6 (/ISS) |
|
Histone H4-K12 acetylation GO:0043983
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.
|
1 | Q9JHD2 (/IDA) |
|
Histone H3-K14 acetylation GO:0044154
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.
|
1 | Q9JHD2 (/IDA) |
|
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
|
1 | Q9JHD2 (/IMP) |
|
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
1 | Q92831 (/TAS) |
|
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
|
1 | Q92831 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9JHD2 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | A0A0R4IXF6 (/ISS) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | Q9JHD2 (/IMP) |
|
Intracellular distribution of mitochondria GO:0048312
Any process that establishes the spatial arrangement of mitochondria within the cell.
|
1 | D4ACX5 (/IMP) |
|
Intracellular distribution of mitochondria GO:0048312
Any process that establishes the spatial arrangement of mitochondria within the cell.
|
1 | Q9JHD2 (/ISO) |
|
Regulation of T cell activation GO:0050863
Any process that modulates the frequency, rate or extent of T cell activation.
|
1 | Q9JHD2 (/IMP) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | D4ACX5 (/IEP) |
|
Alpha-tubulin acetylation GO:0071929
The addition of an acetyl group to the lysine 40 residue of alpha-tubulin.
|
1 | D4ACX5 (/IMP) |
|
Alpha-tubulin acetylation GO:0071929
The addition of an acetyl group to the lysine 40 residue of alpha-tubulin.
|
1 | Q9JHD2 (/ISO) |
|
Histone succinylation GO:0106077
The modification of a histone by the addition of an succinyl group.
|
1 | Q92830 (/IDA) |
|
Histone succinylation GO:0106077
The modification of a histone by the addition of an succinyl group.
|
1 | Q9JHD2 (/ISO) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | D4ACX5 (/IEP) |
|
Positive regulation of cardiac muscle cell differentiation GO:2000727
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
|
1 | D4ACX5 (/IMP) |
|
Positive regulation of cardiac muscle cell differentiation GO:2000727
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
|
1 | Q9JHD2 (/ISO) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | D4ACX5 (/IDA) Q92830 (/IDA) Q92831 (/IDA) Q9JHD1 (/IDA) Q9JHD1 (/IDA) Q9JHD2 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
5 | A0A0R4IXF6 (/ISS) Q1LUC3 (/ISS) Q9JHD1 (/ISS) Q9JHD1 (/ISS) Q9JHD2 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | Q92830 (/TAS) Q92831 (/TAS) Q9JHD1 (/TAS) Q9JHD1 (/TAS) |
|
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
|
3 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) Q9JHD2 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | A0A0R4IXF6 (/ISS) Q1LUC3 (/ISS) Q92831 (/ISS) |
|
Ada2/Gcn5/Ada3 transcription activator complex GO:0005671
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
|
3 | Q92830 (/IDA) Q92831 (/IDA) Q9JHD2 (/IDA) |
|
Ada2/Gcn5/Ada3 transcription activator complex GO:0005671
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
3 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) Q9JHD2 (/ISO) |
|
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
2 | Q92830 (/IDA) Q92831 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
STAGA complex GO:0030914
A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs.
|
2 | Q92830 (/IDA) Q9JHD2 (/IDA) |
|
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q9JHD1 (/ISO) Q9JHD1 (/ISO) |
|
Actomyosin GO:0042641
Any complex of actin, myosin, and accessory proteins.
|
2 | Q9JHD1 (/IDA) Q9JHD1 (/IDA) |
|
PCAF complex GO:0000125
A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
|
1 | Q92831 (/NAS) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | D4ACX5 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q92830 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q92831 (/TAS) |
|
STAGA complex GO:0030914
A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs.
|
1 | Q9JHD2 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q92831 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q92831 (/IPI) |
|
Transcription factor TFTC complex GO:0033276
A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.
|
1 | Q92830 (/IDA) |
|
Transcription factor TFTC complex GO:0033276
A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.
|
1 | Q9JHD2 (/ISO) |
|
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
1 | Q9JHD2 (/IDA) |