The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dbl homology (DH) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
885
3D
2nz8B01 - 80.1
2
823
3D
2pz1A02 - 74.7
3
655 - - 92.0
4
601
3D
4d0oB00 - 90.8
6
GEF
544
3D
5jhhE01 - 89.1
5
543 - - 48.2
7
507 - - 93.1
8
454
3D
2rgnE01 - 89.2
9
409
3D
2vrwB01 - 80.4
10
358
3D
2z0qA01 - 60.9
11
307
3D
5hziB01 - 73.4
12
301
3D
1foeG01 - 64.9
13
288 - - 73.2
14
254 - - 59.0
15
245
3D
3ksyA02 - 82.3
16
242
3D
1by1A00 - 81.2
18
221
3D
5fi1A01 - 76.4
17
217 - - 74.4
19
203 - - 81.3
20
198
3D
4gzuB01 - 65.9
21
174 - - 88.0
22
172 - - 63.8
23
161 - - 77.2
24
143
3D
3mpxA01 - 75.1
25
92 - - 68.6
26
80 - - 48.1
27
77 - - 71.9
28
61 - - 59.9
29
57 - - 74.4
30
55 - - 54.5
31
46 - - 21.3
32
41 - - 71.1
33
37 - - 71.1
34
35 - - 13.8
36
32 - - 37.4
35
32 - - 79.0
37
31 - - 19.2
38
28 - - 91.7
39
27 - - 4.5
40
27 - - 16.3
41
24 - - 64.2
42
24 - - 12.8
43
22 - - 38.0
44
21 - - 16.2
46
20 - - 73.4
45
20 - - 55.6
48
17 - - 24.4
49
17 - - 29.0
47
17 - - 17.5
50
16 - - 57.4
51
15 - - 36.4
53
13 - - 76.6
52
13 - - 13.5
54
13 - - 17.5
55
12 - - 8.3
56
11 - - 10.0
57
11 - - 20.7
60
9 - - 30.8
58
9 - - 4.7
59
9 - - 19.5
62
8 - - 14.1
61
Mammalian Tumor Invasion And Metastasis factor
8 - - 7.6
63
GEF
8 - - 91.1
65
7 - - 3.9
64
7 - - 3.3
66
7 - - 10.9
69
6 - - 0.0
67
AFU_orthologue AFUA_5G11890
6 - - 19.9
68
6 - - 1.4
70
Protein4.1-ezrin-radixin-moesin
5 - - 15.1
71
4 - - 39.7
72
4 - - 0.0
73
4 - - 5.7
78
3 - - 0.0
80
3 - - 2.6
76
3 - - 20.7
74
3 - - 0.0
77
3 - - 0.0
79
3 - - 14.0
75
3 - - 12.8
89
PAK (p21-activated kinase
2 - - 0.0
92
2 - - 0.0
82
2 - - 0.0
90
2 - - 0.0
84
2 - - 43.8
96
2 - - 39.4
85
2 - - 43.2
94
2 - - 0.0
87
2 - - 6.8
91
2 - - 4.9
81
2 - - 43.5
93
Mammalian Rho GEF
2 - - 0.0
83
2 - - 6.4
95
2 - - 0.0
86
2 - - 19.1
88
2 - - 10.0
112
1 - - 0.0
105
1 - - 0.0
129
1 - - 0.0
124
1 - - 0.0
99
1 - - 0.0
131
1 - - 0.0
119
1 - - 0.0
110
1 - - 0.0
126
1 - - 0.0
103
1 - - 0.0
133
1 - - 0.0
117
1 - - 0.0
135
1 - - 0.0
109
1 - - 0.0
121
1 - - 0.0
98
1 - - 0.0
107
1 - - 0.0
130
1 - - 0.0
115
1 - - 0.0
123
1 - - 0.0
128
1 - - 0.0
132
1 - - 0.0
111
1 - - 0.0
113
1 - - 0.0
102
1 - - 0.0
125
1 - - 0.0
118
1 - - 0.0
100
1 - - 0.0
134
1 - - 0.0
127
1 - - 0.0
101
GEF
1 - - 0.0
136
1 - - 0.0
116
1 - - 0.0
108
1 - - 0.0
120
1 - - 0.0
106
1 - - 0.0
122
1 - - 0.0
114
1 - - 0.0
104
1 - - 0.0
97
1 - - 0.0