The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: BAG family molecular chaperone regulator 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
4 O95816 (/IDA) O95816 (/IDA) O95816 (/IDA) O95816 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O95816 (/IPI) O95816 (/IPI) O95816 (/IPI) O95816 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O95816 (/IPI) O95816 (/IPI) O95816 (/IPI) O95816 (/IPI)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
4 O95816 (/IPI) O95816 (/IPI) O95816 (/IPI) O95816 (/IPI)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
4 O95816 (/NAS) O95816 (/NAS) O95816 (/NAS) O95816 (/NAS)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
4 O95816 (/IPI) O95816 (/IPI) O95816 (/IPI) O95816 (/IPI)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
2 Q3ZBG5 (/ISS) Q91YN9 (/ISS)
Adenyl-nucleotide exchange factor activity GO:0000774
Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
1 Q91YN9 (/ISO)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 Q91YN9 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q91YN9 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q91YN9 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q91YN9 (/ISO)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
1 Q91YN9 (/IPI)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 Q91YN9 (/ISO)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
4 O95816 (/TAS) O95816 (/TAS) O95816 (/TAS) O95816 (/TAS)
Positive regulation of protein processing GO:0010954
Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
4 O95816 (/IMP) O95816 (/IMP) O95816 (/IMP) O95816 (/IMP)
Protein metabolic process GO:0019538
The chemical reactions and pathways involving a protein. Includes protein modification.
4 O95816 (/IDA) O95816 (/IDA) O95816 (/IDA) O95816 (/IDA)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
4 O95816 (/IDA) O95816 (/IDA) O95816 (/IDA) O95816 (/IDA)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
4 O95816 (/ISS) O95816 (/ISS) O95816 (/ISS) O95816 (/ISS)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
4 O95816 (/IDA) O95816 (/IDA) O95816 (/IDA) O95816 (/IDA)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
4 O95816 (/IDA) O95816 (/IDA) O95816 (/IDA) O95816 (/IDA)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
4 O95816 (/TAS) O95816 (/TAS) O95816 (/TAS) O95816 (/TAS)
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
4 O95816 (/ISS) O95816 (/ISS) O95816 (/ISS) O95816 (/ISS)
Negative regulation of ubiquitin protein ligase activity GO:1904667
Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
4 O95816 (/IDA) O95816 (/IDA) O95816 (/IDA) O95816 (/IDA)
Positive regulation of protein processing GO:0010954
Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
1 Q91YN9 (/ISO)
Protein metabolic process GO:0019538
The chemical reactions and pathways involving a protein. Includes protein modification.
1 Q91YN9 (/ISO)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q91YN9 (/IGI)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q91YN9 (/ISO)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q91YN9 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 Q91YN9 (/ISO)
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
1 Q91YN9 (/IGI)
Negative regulation of ubiquitin protein ligase activity GO:1904667
Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
1 Q91YN9 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O95816 (/TAS) O95816 (/TAS) O95816 (/TAS) O95816 (/TAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
4 O95816 (/ISS) O95816 (/ISS) O95816 (/ISS) O95816 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
4 O95816 (/ISS) O95816 (/ISS) O95816 (/ISS) O95816 (/ISS)
Chaperone complex GO:0101031
A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
4 O95816 (/IPI) O95816 (/IPI) O95816 (/IPI) O95816 (/IPI)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q91YN9 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q91YN9 (/IDA)
Chaperone complex GO:0101031
A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
1 Q91YN9 (/ISO)