The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Formin, FH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Formin, FH2 domain

Formins are multi-domain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains PMID:12538772.

This superfamily represents the formin homology 2 (FH2) domain which plays a role in the nucleation of actin filaments; it remains bound to the barbed end of the growing filament. The domain is involved in processive capping of the actin filament, which is based on a structural unit, the FH2 actin bridge, that binds the barbed end and blocks monomer binding and release. In the FH2 dimer, the second bridge element provides functionality that can overcome the inhibitory properties of the first.

PFAM:PF02181,INTERPRO:IPR015425,DOI:10.1038/nature03251

GO Diversity

Unique GO annotations
285 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1582 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 25
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 6
Unique PDBs: 9
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 72
Function
Unique EC:
Unique GO: 285
Taxonomy
Unique Species: 1582