The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Tubulin Binding Cofactor C, N-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Tubulin Binding Cofactor C, N-terminal domain

Tubulin Binding Cofactor C (TBCC) is a post-chaperonin involved in the folding and assembly of alpha- and beta-tubulin monomers leading to the release of productive tubulin heterodimers ready to polymerise into microtubules. TBCC is found at the centrosome and is implicated in bipolar spindle formation. This chaperonin is organised into three different domains: N-terminal, CARP and C-terminal. The N-terminal comprises a structured coiled coil and a highly dynamic N-terminal region which concentrates 80% of charged and polar residues and is believed to be important in interaction with tubulin. Overall, the N-terminal domain of TBCC is responsible for its interaction with components of the centrosome by its N-terminal domain.

GO Diversity

Unique GO annotations
11 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1008 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 9
Unique EC:
Unique GO: 11
Unique Species: 1008