The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

DnaG, RNA polymerase domain, helical bundle

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DnaG, RNA polymerase domain, helical bundle

This superfamily comprises the C-terminal region, helical bundle (HB) domain of DNA primase DnaG mostly found in bacteria PMID:10741967,PMID:22795082. Primases synthesise short RNA strands on single-stranded DNA templates, thereby generating the hybrid duplexes required for the initiation of synthesis by DNA polymerases. In bacteria, a protein known as DnaG is responsible for catalysing primer synthesis during DNA replication PMID:22795082. Primases are recruited to single-stranded DNA by helicases - this domain binds DnaB-helicase PMID:10873470. It is associated with the Toprim domain PFAM:PF01751, INTERPRO:IPR006171, which is the central catalytic core.

PFAM:PF10410, INTERPRO:IPR019475,DOI:10.1126/science.287.5462.2482,DOI:10.1016/j.str.2012.05.017

GO Diversity

Unique GO annotations
5 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
2486 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 18
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 12
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 7
Unique EC:
Unique GO: 5
Unique Species: 2486