The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Myosin heavy chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 P13533 (/IDA)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 P13533 (/ISS)
Motor activity GO:0003774
Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate.
1 Q60LV4 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P13533 (/IDA)
Myosin phosphatase activity GO:0017018
Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
1 P13533 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P13533 (/IPI)
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
1 P13533 (/IMP)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extraocular skeletal muscle development GO:0002074
The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.
2 A0A0G2JY53 (/IEP) A0A0G2JY53 (/IEP)
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
2 P13533 (/IMP) Q910C5 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
2 P29616 (/IEP) Q91411 (/IEP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
2 I6L963 (/IDA) Q7T2Y2 (/IDA)
Atrial cardiac muscle tissue morphogenesis GO:0055009
The process in which the anatomical structure of cardiac atrium muscle is generated and organized.
2 P13533 (/IMP) Q910C5 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P13533 (/ISS)
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
1 I6L963 (/IMP)
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
1 P13533 (/IDA)
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
1 P13533 (/ISS)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
1 P13533 (/IDA)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 P13533 (/IDA)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 I6L963 (/ISO)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 P13533 (/IMP)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 P13533 (/ISS)
Visceral muscle development GO:0007522
The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.
1 P13533 (/ISS)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 Q60LV4 (/ISS)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 P13533 (/ISS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 P13533 (/ISS)
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
1 P13533 (/IMP)
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
1 P13533 (/TAS)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
1 P13533 (/ISS)
Regulation of ATPase activity GO:0043462
Any process that modulates the rate of ATP hydrolysis by an ATPase.
1 P13533 (/ISS)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 P13533 (/ISS)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
1 P13533 (/IDA)
Cardiac muscle fiber development GO:0048739
The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.
1 P13533 (/ISS)
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
1 P13533 (/IMP)
Atrial cardiac muscle cell development GO:0055014
The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ.
1 P29616 (/IMP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 P13533 (/ISS)
Actin-mediated cell contraction GO:0070252
The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
1 I6L963 (/IDA)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
3 P13533 (/ISS) P13540 (/ISS) Q9BE39 (/ISS)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
2 P13540 (/ISS) Q9BE39 (/ISS)
Myosin filament GO:0032982
A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.
2 P13540 (/ISS) Q9BE39 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 I6L963 (/IMP)
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.
1 I6L963 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P13533 (/TAS)
Muscle myosin complex GO:0005859
A filament of myosin found in a muscle cell of any type.
1 I6L963 (/ISO)
Muscle myosin complex GO:0005859
A filament of myosin found in a muscle cell of any type.
1 P13533 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 I6L963 (/IDA)
Myosin complex GO:0016459
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
1 P13533 (/TAS)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
1 I6L963 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
1 I6L963 (/ISO)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 P13533 (/TAS)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
1 I6L963 (/IDA)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
1 Q60LV4 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 I6L963 (/ISO)
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
1 A2AQP0 (/IDA)