The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: Myosin heavy chain 6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
2 Q02566 (/IMP) Q02566 (/IMP)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
2 Q02566 (/ISO) Q02566 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q02566 (/IPI) Q02566 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q02566 (/ISO) Q02566 (/ISO)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
2 Q02566 (/ISO) Q02566 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q02566 (/ISO) Q02566 (/ISO)
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
2 Q02566 (/ISO) Q02566 (/ISO)
Calcium-dependent ATPase activity GO:0030899
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).
2 Q02566 (/ISO) Q02566 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q02566 (/ISO) Q02566 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q02566 (/ISO) Q02566 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 Q02566 (/ISO) Q02566 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
2 Q02566 (/IMP) Q02566 (/IMP)
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
2 Q02566 (/IMP) Q02566 (/IMP)
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
2 Q02566 (/ISO) Q02566 (/ISO)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
2 Q02566 (/IMP) Q02566 (/IMP)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
2 Q02566 (/ISO) Q02566 (/ISO)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
2 Q02566 (/ISO) Q02566 (/ISO)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
2 Q02566 (/IMP) Q02566 (/IMP)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
2 Q02566 (/ISO) Q02566 (/ISO)
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
2 Q02566 (/IMP) Q02566 (/IMP)
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
2 Q02566 (/ISO) Q02566 (/ISO)
Visceral muscle development GO:0007522
The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.
2 Q02566 (/IMP) Q02566 (/IMP)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
2 Q02566 (/IMP) Q02566 (/IMP)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 Q02566 (/IMP) Q02566 (/IMP)
Cardiac muscle hypertrophy in response to stress GO:0014898
The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis.
2 Q02566 (/IDA) Q02566 (/IDA)
Actin filament-based movement GO:0030048
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
2 Q02566 (/IMP) Q02566 (/IMP)
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
2 Q02566 (/ISO) Q02566 (/ISO)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
2 Q02566 (/IMP) Q02566 (/IMP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q02566 (/IDA) Q02566 (/IDA)
Regulation of ATPase activity GO:0043462
Any process that modulates the rate of ATP hydrolysis by an ATPase.
2 Q02566 (/IMP) Q02566 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
2 Q02566 (/IMP) Q02566 (/IMP)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
2 Q02566 (/ISO) Q02566 (/ISO)
Cardiac muscle fiber development GO:0048739
The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.
2 Q02566 (/IMP) Q02566 (/IMP)
Atrial cardiac muscle tissue morphogenesis GO:0055009
The process in which the anatomical structure of cardiac atrium muscle is generated and organized.
2 Q02566 (/ISO) Q02566 (/ISO)
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
2 Q02566 (/ISO) Q02566 (/ISO)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
2 Q02566 (/IMP) Q02566 (/IMP)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
2 Q02566 (/IDA) Q02566 (/IDA)
Regulation of heart growth GO:0060420
Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
2 Q02566 (/IDA) Q02566 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
2 Q02566 (/IDA) Q02566 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q02566 (/ISO) Q02566 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q02566 (/ISO) Q02566 (/ISO)
Muscle myosin complex GO:0005859
A filament of myosin found in a muscle cell of any type.
2 Q02566 (/ISO) Q02566 (/ISO)
Myosin complex GO:0016459
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
2 Q02566 (/IDA) Q02566 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
2 Q02566 (/IDA) Q02566 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
2 Q02566 (/ISO) Q02566 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
2 Q02566 (/IDA) Q02566 (/IDA)