CATH Superfamily 1.20.5.340
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 24: Forkhead box P3, isoform CRA_b
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 29 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q9BZS1 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q99JB6 (/IPI) Q99JB6 (/IPI) Q9BZS1 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q6U8D7 (/ISS) Q6U8D7 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q9BZS1 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q9BZS1 (/ISM) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q9BZS1 (/IMP) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q9BZS1 (/NAS) |
|
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
|
1 | Q9BZS1 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q9BZS1 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
1 | Q9BZS1 (/IPI) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q9BZS1 (/NAS) |
|
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
|
1 | Q9BZS1 (/IPI) |
There are 123 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
8 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) Q9BZS1 (/ISS) |
|
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
|
4 | Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment GO:0002362
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
|
3 | Q99JB6 (/TAS) Q99JB6 (/TAS) Q9BZS1 (/TAS) |
|
Regulation of T cell anergy GO:0002667
Any process that modulates the frequency, rate, or extent of T cell anergy.
|
3 | Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q9BZS1 (/ISS) |
|
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
3 | Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP) |
|
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
3 | Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP) |
|
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
|
3 | Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP) |
|
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831
Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.
|
3 | Q99JB6 (/TAS) Q99JB6 (/TAS) Q9BZS1 (/TAS) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
3 | Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
B cell homeostasis GO:0001782
The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | Q99JB6 (/IGI) Q99JB6 (/IGI) |
|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Myeloid cell homeostasis GO:0002262
The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0002361
The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Tolerance induction GO:0002507
A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Tolerance induction to self antigen GO:0002513
Tolerance induction directed at self antigens.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Regulation of immunoglobulin production GO:0002637
Any process that modulates the frequency, rate, or extent of immunoglobulin production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Positive regulation of T cell tolerance induction GO:0002666
Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Regulation of T cell anergy GO:0002667
Any process that modulates the frequency, rate, or extent of T cell anergy.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Positive regulation of T cell anergy GO:0002669
Any process that activates or increases the frequency, rate, or extent of T cell anergy.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of chronic inflammatory response GO:0002677
Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of chronic inflammatory response GO:0002677
Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Positive regulation of peripheral T cell tolerance induction GO:0002851
Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q99JB6 (/IGI) Q99JB6 (/IGI) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of histone deacetylation GO:0031064
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interleukin-5 production GO:0032714
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of interleukin-5 production GO:0032714
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831
Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Positive regulation of transforming growth factor beta1 production GO:0032914
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Positive regulation of immature T cell proliferation in thymus GO:0033092
Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of histone acetylation GO:0035067
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of interferon-gamma biosynthetic process GO:0045077
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q99JB6 (/IDA) Q99JB6 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of isotype switching to IgE isotypes GO:0048294
Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Regulation of isotype switching to IgG isotypes GO:0048302
Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of lymphocyte proliferation GO:0050672
Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
2 | Q99JB6 (/IMP) Q99JB6 (/IMP) |
|
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0002361
The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
|
1 | B7ZLG1 (/IMP) |
|
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
|
1 | Q9BZS1 (/IDA) |
|
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
|
1 | Q9BZS1 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q9BZS1 (/NAS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9BZS1 (/NAS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q9BZS1 (/IDA) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
1 | Q9BZS1 (/IEP) |
|
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
|
1 | Q9BZS1 (/TAS) |
|
Negative regulation of histone deacetylation GO:0031064
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.
|
1 | Q9BZS1 (/IGI) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
1 | Q9BZS1 (/IDA) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
1 | Q9BZS1 (/IDA) |
|
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
|
1 | Q9BZS1 (/IDA) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
1 | Q9BZS1 (/IMP) |
|
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
|
1 | Q9BZS1 (/IDA) |
|
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
1 | Q9BZS1 (/IDA) |
|
T cell homeostasis GO:0043029
The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | Q9BZS1 (/NAS) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | Q9BZS1 (/IDA) |
|
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
1 | Q9BZS1 (/IMP) |
|
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
|
1 | Q9BZS1 (/TAS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9BZS1 (/IMP) |
|
Negative regulation of activated T cell proliferation GO:0046007
Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
|
1 | Q9BZS1 (/NAS) |
|
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
|
1 | Q9BZS1 (/IDA) |
|
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | Q9BZS1 (/IDA) |
|
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
|
1 | Q9BZS1 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q2LEZ0 (/ISS) Q5MAV9 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | A0A0C4DFW6 (/IDA) B7ZLG1 (/IDA) Q9BZS1 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q99JB6 (/ISO) Q99JB6 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q6U8D7 (/ISS) Q6U8D7 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9BZS1 (/TAS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q9BZS1 (/NAS) |