The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Amino acid/polyamine transporter I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: General amino acid permease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basic amino acid transmembrane transporter activity GO:0015174
Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7.
8 P04817 (/IDA) P04817 (/IDA) P32487 (/IDA) P32487 (/IDA) P32487 (/IDA) P32487 (/IDA) P38971 (/IDA) P38971 (/IDA)
High-affinity tryptophan transmembrane transporter activity GO:0005300
Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
6 P38967 (/IMP) P38967 (/IMP) P38967 (/IMP) P38967 (/IMP) P38967 (/IMP) P38967 (/IMP)
Aromatic amino acid transmembrane transporter activity GO:0015173
Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.
6 P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA)
Dicarboxylic acid transmembrane transporter activity GO:0005310
Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.
4 P53388 (/IDA) P53388 (/IDA) P53388 (/IDA) P53388 (/IDA)
Neutral amino acid transmembrane transporter activity GO:0015175
Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7.
4 P15380 (/IDA) P15380 (/IDA) P15380 (/IDA) P15380 (/IDA)
L-proline transmembrane transporter activity GO:0015193
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
4 P15380 (/IGI) P15380 (/IGI) P15380 (/IGI) P15380 (/IGI)
L-proline transmembrane transporter activity GO:0015193
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
4 P15380 (/IMP) P15380 (/IMP) P15380 (/IMP) P15380 (/IMP)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
3 O74543 (/ISM) P40901 (/ISM) Q9HDV2 (/ISM)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
2 Q59WB3 (/IDA) Q59WB3 (/IDA)
Arginine transmembrane transporter activity GO:0015181
Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.
2 P04817 (/IMP) P04817 (/IMP)
L-histidine transmembrane transporter activity GO:0005290
Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
1 A0A1D8PPI5 (/IDA)
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
1 C8V2E0 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P38090 (/IPI)
Basic amino acid transmembrane transporter activity GO:0015174
Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7.
1 A0A1D8PPI5 (/ISS)
Arginine transmembrane transporter activity GO:0015181
Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.
1 A0A1D8PPI5 (/IDA)
Arginine transmembrane transporter activity GO:0015181
Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.
1 A0A1D8PPI5 (/NAS)
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
1 C8V2E0 (/IDA)
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
1 C8V2E0 (/IMP)
L-lysine transmembrane transporter activity GO:0015189
Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.
1 A0A1D8PPI5 (/IDA)
L-proline transmembrane transporter activity GO:0015193
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
1 Q9URZ3 (/ISO)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
1 A0A1D8PPI5 (/NAS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basic amino acid transport GO:0015802
The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 A0A1D8PPI5 (/IDA) P04817 (/IDA) P04817 (/IDA) P32487 (/IDA) P32487 (/IDA) P32487 (/IDA) P32487 (/IDA) P38971 (/IDA) P38971 (/IDA)
Aromatic amino acid transport GO:0015801
The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA)
Tryptophan transport GO:0015827
The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P38967 (/IMP) P38967 (/IMP) P38967 (/IMP) P38967 (/IMP) P38967 (/IMP) P38967 (/IMP)
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P53388 (/IDA) P53388 (/IDA) P53388 (/IDA) P53388 (/IDA)
Neutral amino acid transport GO:0015804
The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P15380 (/IDA) P15380 (/IDA) P15380 (/IDA) P15380 (/IDA)
Gamma-aminobutyric acid transport GO:0015812
The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P15380 (/IDA) P15380 (/IDA) P15380 (/IDA) P15380 (/IDA)
Gamma-aminobutyric acid transport GO:0015812
The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P15380 (/IGI) P15380 (/IGI) P15380 (/IGI) P15380 (/IGI)
Proline transport GO:0015824
The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P15380 (/IDA) P15380 (/IDA) P15380 (/IDA) P15380 (/IDA)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
3 O74543 (/ISM) P40901 (/ISM) Q9HDV2 (/ISM)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
2 Q59WB3 (/IMP) Q59WB3 (/IMP)
S-adenosyl-L-methionine transport GO:0015805
The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q59WB3 (/IMP) Q59WB3 (/IMP)
Arginine transport GO:0015809
The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P04817 (/IGI) P04817 (/IGI)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
2 P04817 (/IDA) P04817 (/IDA)
Basic amino acid transport GO:0015802
The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 A0A1D8PPI5 (/ISS)
Arginine transport GO:0015809
The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 A0A1D8PPI5 (/NAS)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
1 C8V2E0 (/IDA)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
1 C8V2E0 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PCR4 (/IMP)
L-aspartate transmembrane transport GO:0070778
The directed movement of L-aspartate across a membrane.
1 C8V2E0 (/IDA)
L-aspartate transmembrane transport GO:0070778
The directed movement of L-aspartate across a membrane.
1 C8V2E0 (/IMP)
Positive regulation of polyamine transmembrane transport GO:1902269
Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport.
1 P38090 (/IMP)
Positive regulation of (R)-carnitine transmembrane transport GO:1902274
Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport.
1 P38090 (/IMP)
Proline import across plasma membrane GO:1905647
The directed movement of proline from outside of a cell into the cytoplasmic compartment.
1 Q9URZ3 (/NAS)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
15 O74543 (/HDA) P04817 (/HDA) P04817 (/HDA) P38090 (/HDA) P38967 (/HDA) P38967 (/HDA) P38967 (/HDA) P38967 (/HDA) P38967 (/HDA) P38967 (/HDA)
(5 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 A0A1D8PCR4 (/IDA) C8V2E0 (/IDA) P04817 (/IDA) P04817 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA) P38967 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P04817 (/HDA) P04817 (/HDA) P32487 (/HDA) P32487 (/HDA) P32487 (/HDA) P32487 (/HDA)
Eisosome GO:0032126
A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.
6 P04817 (/IDA) P04817 (/IDA) P32487 (/IDA) P32487 (/IDA) P32487 (/IDA) P32487 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
4 P53388 (/HDA) P53388 (/HDA) P53388 (/HDA) P53388 (/HDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
4 P53388 (/HDA) P53388 (/HDA) P53388 (/HDA) P53388 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P53388 (/HDA) P53388 (/HDA) P53388 (/HDA) P53388 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P15380 (/ISS) P15380 (/ISS) P15380 (/ISS) P15380 (/ISS)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
4 P53388 (/HDA) P53388 (/HDA) P53388 (/HDA) P53388 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O74543 (/HDA) Q9URZ3 (/HDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 P04817 (/IDA) P04817 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 C8V2E0 (/IDA)
Fungal-type vacuole lumen GO:0000328
The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
1 C8V2E0 (/IDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
1 P38090 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 P38090 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A0A1D8PPI5 (/IGI)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9URZ3 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A0A1D8PPI5 (/NAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P38090 (/IDA)