The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Amino acid/polyamine transporter I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Amino-acid permease, putative

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Choline transmembrane transporter activity GO:0015220
Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
Ethanolamine transmembrane transporter activity GO:0034228
Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
(R)-carnitine transmembrane transporter activity GO:1901235
Enables the transfer of (R)-carnitine from one side of a membrane to the other.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
7 O59813 (/ISM) O60113 (/ISM) O74537 (/ISM) Q09887 (/ISM) Q10087 (/ISM) Q9C0Z0 (/ISM) Q9US40 (/ISM)
Putrescine transmembrane transporter activity GO:0015489
Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
3 P32837 (/IMP) P32837 (/IMP) P32837 (/IMP)
Gamma-aminobutyric acid:proton symporter activity GO:0015495
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in).
3 P32837 (/IGI) P32837 (/IGI) P32837 (/IGI)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
3 P53744 (/IDA) P53744 (/IDA) P53744 (/IDA)
Gamma-aminobutyric acid transmembrane transporter activity GO:0015185
Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA).
1 A0A1D8PDH1 (/IGI)
Polyamine transmembrane transporter activity GO:0015203
Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.
1 A0A1D8PDH1 (/IGI)
Thiamine transmembrane transporter activity GO:0015234
Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.
1 Q9UT18 (/IDA)
Thiamine transmembrane transporter activity GO:0015234
Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.
1 Q9UT18 (/IGI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Choline transport GO:0015871
The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
Glycine betaine transport GO:0031460
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
Ethanolamine transport GO:0034229
The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
(R)-carnitine transport GO:1900749
The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP) P19807 (/IMP)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
6 O60113 (/ISM) O74537 (/ISM) Q09887 (/ISM) Q10087 (/ISM) Q9C0Z0 (/ISM) Q9US40 (/ISM)
Gamma-aminobutyric acid transport GO:0015812
The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 P32837 (/IMP) P32837 (/IMP) P32837 (/IMP) Q5B918 (/IMP) Q5B918 (/IMP)
Gamma-aminobutyric acid transport GO:0015812
The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 A0A1D8PDH1 (/IGI) P32837 (/IGI) P32837 (/IGI) P32837 (/IGI)
Biotin biosynthetic process GO:0009102
The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
3 P53744 (/IMP) P53744 (/IMP) P53744 (/IMP)
Putrescine transport GO:0015847
The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
3 P32837 (/IMP) P32837 (/IMP) P32837 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 A0A1D8PGA9 (/IMP) A0A1D8PGA9 (/IMP) A0A1D8PH79 (/IMP)
Vitamin transport GO:0051180
The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
3 P53744 (/IDA) P53744 (/IDA) P53744 (/IDA)
Vitamin transport GO:0051180
The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
3 P53744 (/IMP) P53744 (/IMP) P53744 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
3 P32837 (/IGI) P32837 (/IGI) P32837 (/IGI)
Gamma-aminobutyric acid transport GO:0015812
The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q5B918 (/ISA) Q5B918 (/ISA)
Cellular response to pH GO:0071467
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
2 Q5B918 (/IDA) Q5B918 (/IDA)
Polyamine transport GO:0015846
The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 A0A1D8PDH1 (/IGI)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
1 O59813 (/ISM)
Thiamine import across plasma membrane GO:0140125
The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.
1 Q9UT18 (/IDA)
Thiamine import across plasma membrane GO:0140125
The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.
1 Q9UT18 (/IGI)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
12 P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P53744 (/HDA) P53744 (/HDA)
(2 more)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
8 P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA) P19807 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O74537 (/HDA) Q10087 (/HDA) Q9C0Z0 (/HDA) Q9US40 (/HDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
3 P32837 (/HDA) P32837 (/HDA) P32837 (/HDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
3 P32837 (/IDA) P32837 (/IDA) P32837 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 Q09887 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O60113 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9UT18 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O59813 (/ISM)
Plasma membrane of cell tip GO:0031520
The portion of the plasma membrane surrounding the cell tip.
1 Q9UT18 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 O60113 (/HDA)
Medial membrane band GO:0032178
A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.
1 Q9UT18 (/IDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 O60113 (/HDA)