The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Amino acid/polyamine transporter I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Amino acid permease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
105 P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP) P25737 (/IMP)
(95 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
102 P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA)
(92 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
102 P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA)
(92 more)
Beta-alanine transmembrane transporter activity GO:0001761
Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
L-alanine transmembrane transporter activity GO:0015180
Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
Glycine transmembrane transporter activity GO:0015187
Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
D-alanine transmembrane transporter activity GO:0042944
Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
D-serine transmembrane transporter activity GO:0042945
Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
L-tyrosine transmembrane transporter activity GO:0005302
Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
L-tyrosine transmembrane transporter activity GO:0005302
Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.
33 P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP)
(23 more)
Proton motive force dependent protein transmembrane transporter activity GO:0009977
Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
L-phenylalanine transmembrane transporter activity GO:0015192
Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
L-phenylalanine transmembrane transporter activity GO:0015192
Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid.
33 P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP)
(23 more)
L-tryptophan transmembrane transporter activity GO:0015196
Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
3 P43548 (/IDA) P43548 (/IDA) P43548 (/IDA)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
2 O60170 (/ISM) Q9C0V0 (/ISM)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
2 A0A0F7RMA1 (/ISS) A0A0F7RMA1 (/ISS)
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
2 Q6FK93 (/IDA) Q6FK93 (/IDA)
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
2 Q6FK93 (/IMP) Q6FK93 (/IMP)
L-lysine transmembrane transporter activity GO:0015189
Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.
2 Q81NU6 (/ISS) Q81NU6 (/ISS)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2 A0A0F7RMA1 (/ISS) A0A0F7RMA1 (/ISS)
S-methylmethionine transmembrane transporter activity GO:0000100
Enables the transfer of S-methylmethionine from one side of a membrane to the other.
1 Q47689 (/IMP)
L-leucine transmembrane transporter activity GO:0015190
Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid.
1 O59831 (/IMP)
L-serine transmembrane transporter activity GO:0015194
Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid.
1 Q5A695 (/NAS)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
102 P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA) P25737 (/IDA)
(92 more)
Beta-alanine transport GO:0001762
The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
L-alanine transport GO:0015808
The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
Glycine transport GO:0015816
The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
D-alanine transport GO:0042941
The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
D-serine transport GO:0042942
The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
88 P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP) P0AAE0 (/IMP)
(78 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
57 P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP) P25527 (/IEP)
(47 more)
Phenylalanine transport GO:0015823
The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
Phenylalanine transport GO:0015823
The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP)
(23 more)
Tryptophan transport GO:0015827
The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
Tyrosine transport GO:0015828
The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(23 more)
Tyrosine transport GO:0015828
The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
33 P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP) P15993 (/IMP)
(23 more)
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
12 A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS) A0A0F7RDH0 (/ISS)
(2 more)
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
9 Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA) Q9I703 (/IDA)
L-arginine transport GO:1902023
The directed movement of a L-arginine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP) Q8VKK1 (/IMP)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
5 P39137 (/IDA) P39137 (/IDA) P39137 (/IDA) P39137 (/IDA) P39137 (/IDA)
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P43548 (/IDA) P43548 (/IDA) P43548 (/IDA)
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P43548 (/IMP) P43548 (/IMP) P43548 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
3 P43548 (/IDA) P43548 (/IDA) P43548 (/IDA)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
2 O60170 (/ISM) Q9C0V0 (/ISM)
L-cystine transport GO:0015811
The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q6FK93 (/IMP) Q6FK93 (/IMP)
Sulfur utilization GO:0006791
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism.
1 Q5A695 (/NAS)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
1 Q47689 (/IMP)
S-methylmethionine transport GO:0015806
The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q47689 (/IMP)
Leucine import across plasma membrane GO:0098713
The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol.
1 O59831 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
520 P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA) P0AAE0 (/IDA)
(510 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
135 P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA) P15993 (/IDA)
(125 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
88 P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA) P0AAE0 (/RCA)
(78 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
15 P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA) P9WQM7 (/HDA)
(5 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 O59831 (/HDA) P43548 (/HDA) P43548 (/HDA) P43548 (/HDA) Q9C0V0 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O33203 (/HDA) O33203 (/HDA) O33203 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O33203 (/HDA) O33203 (/HDA) O33203 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O59831 (/HDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O60170 (/ISM)