The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Outer membrane efflux proteins (OEP)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: TolC outer membrane channel

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
68 P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI)
(58 more)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
Porin activity GO:0015288
Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
61 P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP)
(51 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
61 P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI)
(51 more)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
61 P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI)
(51 more)
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
7 Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
61 P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP)
(51 more)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
Enterobactin transport GO:0042930
The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
61 P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI) P02930 (/IGI)
(51 more)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
61 P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP) P02930 (/IMP)
(51 more)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
6 Q9K2Y1 (/ISS) Q9K2Y1 (/ISS) Q9K2Y1 (/ISS) Q9K2Y1 (/ISS) Q9K2Y1 (/ISS) Q9K2Y1 (/ISS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell outer membrane GO:0009279
A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
MacAB-TolC complex GO:1990196
The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC.
61 P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA) P02930 (/IDA)
(51 more)
Efflux pump complex GO:1990281
A protein complex that is capable of efflux transmembrane transporter activity.
61 P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI) P02930 (/IPI)
(51 more)
Efflux pump complex GO:1990281
A protein complex that is capable of efflux transmembrane transporter activity.
7 Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA) Q8ZLZ4 (/IDA)