The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Tumor necrosis factor alpha-induced protein 8-like

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Tumor necrosis factor alpha-induced protein 8-like

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of the family of apoptotic regulators, TNFAIP8 (an alternative name is TIPE) which includes several proteins such as TIPE1, TIPE2 and TIPE3 (INTERPRO:IPR038355). The central cavity that can be observed in the structure of this superfamilies's representative domain has suggested to be involved in co-factor binding PMID:19079267

GO Diversity

Unique GO annotations
32 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
399 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC:
Unique GO: 32
Unique Species: 399