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CATH Superfamily 1.20.144.10

Phosphatidic acid phosphatase type 2/haloperoxidase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidic acid phosphatase type 2/haloperoxidase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: Lipid phosphate phosphatase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphatidate phosphatase. [EC: 3.1.3.4]
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
  • This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol.
  • In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation.
  • The mammalian enzymes are known as lipins.
 4 N1P5U3 N1P5U3 Q04396 Q04396
Diacylglycerol diphosphate phosphatase. [EC: 3.1.3.81]
1,2-diacyl-sn-glycerol 3-diphosphate + H(2)O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.
  • The bifunctional enzyme catalyzes the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. EC 3.1.3.4).
  • It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signaling role in stress response.
  • The phosphatase activity of the bifunctional enzyme is Mg(2+)- independent and N-ethylmaleimide-insensitive and is distinct from the Mg(2+)-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4.
  • The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase.
 4 N1P5U3 N1P5U3 Q04396 Q04396