The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NCX, central ion-binding region
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Sodium/potassium/calcium exchanger 2 isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
9 B1AXF2 (/ISO) B1AXF3 (/ISO) Q14AY1 (/ISO) Q14BI1 (/ISO) Q3UWW4 (/ISO) Q8BUN9 (/ISO) Q8BYP4 (/ISO) Q8BZJ3 (/ISO) Q91WD8 (/ISO)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
8 B1AXF2 (/IDA) B1AXF3 (/IDA) Q14AY1 (/IDA) Q14BI1 (/IDA) Q3UWW4 (/IDA) Q8BUN9 (/IDA) Q8BYP4 (/IDA) Q8BZJ3 (/IDA)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
8 B1AXF2 (/ISO) B1AXF3 (/ISO) Q14AY1 (/ISO) Q14BI1 (/ISO) Q3UWW4 (/ISO) Q8BUN9 (/ISO) Q8BYP4 (/ISO) Q8BZJ3 (/ISO)
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
4 O54701 (/IDA) Q9QZM6 (/IDA) Q9U6A0 (/IDA) Q9UI40 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O60721 (/IPI)
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
1 O54701 (/IMP)
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
1 Q9U6A0 (/ISS)
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
1 O60721 (/NAS)
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
1 Q28139 (/TAS)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 O54701 (/IMP)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 B1AXF2 (/IDA) B1AXF3 (/IDA) Q14AY1 (/IDA) Q14BI1 (/IDA) Q3UWW4 (/IDA) Q8BUN9 (/IDA) Q8BYP4 (/IDA) Q8BZJ3 (/IDA) Q9U6A0 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
9 B1AXF2 (/ISO) B1AXF3 (/ISO) Q14AY1 (/ISO) Q14BI1 (/ISO) Q3UWW4 (/ISO) Q8BUN9 (/ISO) Q8BYP4 (/ISO) Q8BZJ3 (/ISO) Q91WD8 (/ISO)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
8 B1AXF2 (/IMP) B1AXF3 (/IMP) Q14AY1 (/IMP) Q14BI1 (/IMP) Q3UWW4 (/IMP) Q8BUN9 (/IMP) Q8BYP4 (/IMP) Q8BZJ3 (/IMP)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
8 B1AXF2 (/IMP) B1AXF3 (/IMP) Q14AY1 (/IMP) Q14BI1 (/IMP) Q3UWW4 (/IMP) Q8BUN9 (/IMP) Q8BYP4 (/IMP) Q8BZJ3 (/IMP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
8 B1AXF2 (/IMP) B1AXF3 (/IMP) Q14AY1 (/IMP) Q14BI1 (/IMP) Q3UWW4 (/IMP) Q8BUN9 (/IMP) Q8BYP4 (/IMP) Q8BZJ3 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
8 B1AXF2 (/ISO) B1AXF3 (/ISO) Q14AY1 (/ISO) Q14BI1 (/ISO) Q3UWW4 (/ISO) Q8BUN9 (/ISO) Q8BYP4 (/ISO) Q8BZJ3 (/ISO)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
8 B1AXF2 (/IMP) B1AXF3 (/IMP) Q14AY1 (/IMP) Q14BI1 (/IMP) Q3UWW4 (/IMP) Q8BUN9 (/IMP) Q8BYP4 (/IMP) Q8BZJ3 (/IMP)
Long-term synaptic depression GO:0060292
A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
8 B1AXF2 (/IMP) B1AXF3 (/IMP) Q14AY1 (/IMP) Q14BI1 (/IMP) Q3UWW4 (/IMP) Q8BUN9 (/IMP) Q8BYP4 (/IMP) Q8BZJ3 (/IMP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 O54701 (/IDA) Q9QZM6 (/IDA) Q9U6A0 (/IDA)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O60721 (/TAS) Q9UI40 (/TAS)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9U6A0 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9U6A0 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9U6A0 (/ISS)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O60721 (/NAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 O60721 (/NAS)
Response to light intensity GO:0009642
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
1 O60721 (/NAS)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 Q9UI40 (/IDA)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
1 Q9U6A0 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
9 B1AXF2 (/ISO) B1AXF3 (/ISO) Q14AY1 (/ISO) Q14BI1 (/ISO) Q3UWW4 (/ISO) Q8BUN9 (/ISO) Q8BYP4 (/ISO) Q8BZJ3 (/ISO) Q91WD8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 B1AXF2 (/IDA) B1AXF3 (/IDA) Q14AY1 (/IDA) Q14BI1 (/IDA) Q3UWW4 (/IDA) Q8BUN9 (/IDA) Q8BYP4 (/IDA) Q8BZJ3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O60721 (/TAS) Q28139 (/TAS) Q9UI40 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O60721 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O60721 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9U6A0 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9U6A0 (/ISS)
Outer membrane GO:0019867
The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
1 O60721 (/NAS)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q9QZM6 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 O54701 (/IMP)