The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dynein heavy chain, N-terminal domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Dynein, axonemal, heavy chain 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
6 A0A0B4K614 (/ISS) A0A0B4K648 (/ISS) A0A0B4LH20 (/ISS) A8Y5B7 (/ISS) Q9GPN7 (/ISS) Q9VH97 (/ISS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
2 A8Y5B7 (/ISS) Q9GPN7 (/ISS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
2 A8Y5B7 (/TAS) Q9GPN7 (/TAS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q8VHE6 (/IMP)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q96JB1 (/NAS)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
6 A0A0B4K614 (/ISS) A0A0B4K648 (/ISS) A0A0B4LH20 (/ISS) A8Y5B7 (/ISS) Q9GPN7 (/ISS) Q9VH97 (/ISS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
4 A0A0B4K614 (/IMP) A0A0B4K648 (/IMP) A0A0B4LH20 (/IMP) Q9VH97 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
2 Q8TE73 (/IMP) Q8VHE6 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
2 Q8TE73 (/IMP) Q8VHE6 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
1 Q8VHE6 (/ISO)
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
1 Q8VHE6 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 Q8VHE6 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q8VHE6 (/IMP)
Lateral ventricle development GO:0021670
The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.
1 Q8VHE6 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q8TE73 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q8VHE6 (/ISO)
Outer dynein arm assembly GO:0036158
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q8TE73 (/IMP)
Outer dynein arm assembly GO:0036158
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q8VHE6 (/ISO)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q8TE73 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q8VHE6 (/ISO)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q96JB1 (/NAS)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
1 K7DY80 (/IGI)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
6 A0A0B4K614 (/ISS) A0A0B4K648 (/ISS) A0A0B4LH20 (/ISS) A8Y5B7 (/ISS) Q9GPN7 (/ISS) Q9VH97 (/ISS)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
3 A8Y5B7 (/IMP) Q8VHE6 (/IMP) Q9GPN7 (/IMP)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
2 Q8TE73 (/IDA) Q8VHE6 (/IDA)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
1 Q96JB1 (/NAS)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q8VHE6 (/ISO)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q96JB1 (/IDA)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q91XQ0 (/ISO)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q8TE73 (/IDA)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q8TE73 (/IMP)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q91XQ0 (/ISM)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q8VHE6 (/ISO)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
1 Q8TE73 (/IDA)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
1 Q8VHE6 (/ISO)