The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: cystinosin isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
4 O60931 (/IMP) O60931 (/IMP) P57757 (/IMP) P57757 (/IMP)
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
2 P57757 (/IDA) P57757 (/IDA)
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
2 P57757 (/ISO) P57757 (/ISO)
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
2 O60931 (/NAS) O60931 (/NAS)
L-cystine transmembrane transporter activity GO:0015184
Enables the transfer of L-cystine from one side of a membrane to the other.
2 O60931 (/TAS) O60931 (/TAS)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-cystine transport GO:0015811
The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 A0A0G2K358 (/IMP) D3ZG79 (/IMP) O60931 (/IMP) O60931 (/IMP) P57757 (/IMP) P57757 (/IMP)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
2 P57757 (/IMP) P57757 (/IMP)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
2 O60931 (/NAS) O60931 (/NAS)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
2 O60931 (/IMP) O60931 (/IMP)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
2 P57757 (/ISO) P57757 (/ISO)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O60931 (/TAS) O60931 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 O60931 (/IMP) O60931 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 P57757 (/ISO) P57757 (/ISO)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 P57757 (/IMP) P57757 (/IMP)
Grooming behavior GO:0007625
The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.
2 P57757 (/IMP) P57757 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 P57757 (/IMP) P57757 (/IMP)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
2 P57757 (/IMP) P57757 (/IMP)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
2 A0A0G2K358 (/IMP) D3ZG79 (/IMP)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
2 P57757 (/ISO) P57757 (/ISO)
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 A0A0G2K358 (/IMP) D3ZG79 (/IMP)
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 P57757 (/ISO) P57757 (/ISO)
L-cystine transport GO:0015811
The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P57757 (/IDA) P57757 (/IDA)
L-cystine transport GO:0015811
The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P57757 (/ISO) P57757 (/ISO)
L-cystine transport GO:0015811
The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O60931 (/NAS) O60931 (/NAS)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
2 O60931 (/IMP) O60931 (/IMP)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
2 P57757 (/ISO) P57757 (/ISO)
Cognition GO:0050890
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
2 O60931 (/IMP) O60931 (/IMP)
Cognition GO:0050890
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
2 P57757 (/ISO) P57757 (/ISO)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
2 O60931 (/TAS) O60931 (/TAS)
Negative regulation of reactive oxygen species biosynthetic process GO:1903427
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
2 A0A0G2K358 (/IMP) D3ZG79 (/IMP)
Negative regulation of reactive oxygen species biosynthetic process GO:1903427
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
2 P57757 (/ISO) P57757 (/ISO)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
5 A0A0S2Z3I9 (/IDA) A0A0S2Z3K3 (/IDA) A0A0S2Z3K3 (/IDA) O60931 (/IDA) O60931 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
5 A0A0S2Z3I9 (/IDA) A0A0S2Z3K3 (/IDA) A0A0S2Z3K3 (/IDA) O60931 (/IDA) O60931 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
4 O60931 (/IDA) O60931 (/IDA) P57757 (/IDA) P57757 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 P57757 (/ISO) P57757 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 O60931 (/HDA) O60931 (/HDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 O60931 (/IDA) O60931 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 P57757 (/ISO) P57757 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 O60931 (/NAS) O60931 (/NAS)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 O60931 (/TAS) O60931 (/TAS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 O60931 (/IDA) O60931 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 P57757 (/ISO) P57757 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P57757 (/ISO) P57757 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 P57757 (/ISO) P57757 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
2 P57757 (/ISO) P57757 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 O60931 (/HDA) O60931 (/HDA)