The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 32: Sorting nexin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q91VH2 (/IPI) Q91VH2 (/IPI) Q9Y5X1 (/IPI) Q9Y5X1 (/IPI)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
4 Q91VH2 (/IDA) Q91VH2 (/IDA) Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 Q9Y5X1 (/IPI) Q9Y5X1 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9Y5X1 (/IPI) Q9Y5X1 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9Y5X1 (/IPI) Q9Y5X1 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
2 Q9Y5X1 (/HDA) Q9Y5X1 (/HDA)
Arp2/3 complex binding GO:0071933
Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Arp2/3 complex binding GO:0071933
Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
2 Q91VH2 (/ISO) Q91VH2 (/ISO)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
4 Q91VH2 (/IMP) Q91VH2 (/IMP) Q9Y5X1 (/IMP) Q9Y5X1 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
2 Q9Y5X1 (/IMP) Q9Y5X1 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q9Y5X1 (/IMP) Q9Y5X1 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2 Q9Y5X1 (/IMP) Q9Y5X1 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 Q9Y5X1 (/IMP) Q9Y5X1 (/IMP)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
2 Q91VH2 (/IDA) Q91VH2 (/IDA)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
2 Q9Y5X1 (/ISS) Q9Y5X1 (/ISS)
Positive regulation of protein oligomerization GO:0032461
Any process that activates or increases the frequency, rate or extent of protein oligomerization.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Positive regulation of protein oligomerization GO:0032461
Any process that activates or increases the frequency, rate or extent of protein oligomerization.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Positive regulation of protein oligomerization GO:0032461
Any process that activates or increases the frequency, rate or extent of protein oligomerization.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Cleavage furrow formation GO:0036089
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
2 Q9Y5X1 (/IMP) Q9Y5X1 (/IMP)
Cleavage furrow formation GO:0036089
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Cleavage furrow formation GO:0036089
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Lipid tube assembly GO:0060988
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Lipid tube assembly GO:0060988
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Lipid tube assembly GO:0060988
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
2 Q9Y5X1 (/TAS) Q9Y5X1 (/TAS)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q91VH2 (/IDA) Q91VH2 (/IDA) Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q91VH2 (/IDA) Q91VH2 (/IDA) Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9Y5X1 (/TAS) Q9Y5X1 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q9Y5X1 (/IDA) Q9Y5X1 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q91VH2 (/ISO) Q91VH2 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q91VH2 (/ISS) Q91VH2 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9Y5X1 (/HDA) Q9Y5X1 (/HDA)