The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Metastasis suppressor 1, isoform CRA_e

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
13 A0A0B4JCQ4 (/IDA) A0A0B4JCZ8 (/IDA) A0A0B4JD47 (/IDA) A0A0B4K7H4 (/IDA) A0A0B4K7T1 (/IDA) A0A0B4K822 (/IDA) A0A0B4KED3 (/IDA) A0A0B4KEE8 (/IDA) A0A0B4KEK0 (/IDA) A0A0B4KEU9 (/IDA)
(3 more)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
13 A0A0B4JCQ4 (/IDA) A0A0B4JCZ8 (/IDA) A0A0B4JD47 (/IDA) A0A0B4K7H4 (/IDA) A0A0B4K7T1 (/IDA) A0A0B4K822 (/IDA) A0A0B4KED3 (/IDA) A0A0B4KEE8 (/IDA) A0A0B4KEK0 (/IDA) A0A0B4KEU9 (/IDA)
(3 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
13 A0A0B4JCQ4 (/IPI) A0A0B4JCZ8 (/IPI) A0A0B4JD47 (/IPI) A0A0B4K7H4 (/IPI) A0A0B4K7T1 (/IPI) A0A0B4K822 (/IPI) A0A0B4KED3 (/IPI) A0A0B4KEE8 (/IPI) A0A0B4KEK0 (/IPI) A0A0B4KEU9 (/IPI)
(3 more)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
2 O43312 (/IDA) Q6P9S0 (/IDA)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
2 Q5ZMW2 (/ISS) Q8R1S4 (/ISS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2 Q765P7 (/IDA) Q765P7 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q5ZMW2 (/ISS) Q8R1S4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O43312 (/IPI) Q8R1S4 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O43312 (/IPI) Q8R1S4 (/IPI)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
2 Q765P7 (/IPI) Q765P7 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q8R1S4 (/IDA)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
1 Q8R1S4 (/ISO)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q6P9S0 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O43312 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q8R1S4 (/ISO)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 Q6P9S0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8R1S4 (/ISO)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q6P9S0 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q6P9S0 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q8R1S4 (/IDA)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Negative regulation of receptor-mediated endocytosis GO:0048261
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
9 D3ZYM5 (/ISS) E1BP52 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Renal tubule morphogenesis GO:0061333
The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
9 D3ZYM5 (/ISS) E1BP52 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
9 D3ZYM5 (/ISS) E1BP52 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Glomerulus morphogenesis GO:0072102
The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
9 D3ZYM5 (/ISS) E1BP52 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Nephron tubule epithelial cell differentiation GO:0072160
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state.
9 D3ZYM5 (/ISS) E1BP52 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013
Any epithelial cell proliferation that is involved in renal tubule morphogenesis.
9 D3ZYM5 (/ISS) E1BP52 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
2 Q765P7 (/IDA) Q765P7 (/IDA)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
2 Q765P7 (/IDA) Q765P7 (/IDA)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q8R1S4 (/IGI)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q8R1S4 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 O43312 (/NAS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O43312 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q8R1S4 (/NAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q8R1S4 (/NAS)
Magnesium ion homeostasis GO:0010960
Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.
1 Q8R1S4 (/IMP)
Microspike assembly GO:0030035
Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.
1 O43312 (/NAS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 O43312 (/TAS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q8R1S4 (/IDA)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
1 Q8R1S4 (/IMP)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
1 Q8R1S4 (/IMP)
Adherens junction maintenance GO:0034334
The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
1 Q8R1S4 (/IMP)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
1 Q6P9S0 (/ISO)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 Q8R1S4 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 Q6P9S0 (/IDA)
Renal tubule morphogenesis GO:0061333
The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
1 Q8R1S4 (/IMP)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 Q8R1S4 (/IDA)
Glomerulus morphogenesis GO:0072102
The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
1 Q8R1S4 (/IMP)
Nephron tubule epithelial cell differentiation GO:0072160
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state.
1 Q8R1S4 (/IMP)
Metanephric tubule development GO:0072170
The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros.
1 Q8R1S4 (/IMP)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
1 Q6P9S0 (/ISO)
Lamellipodium organization GO:0097581
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.
1 Q6P9S0 (/IMP)
Epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013
Any epithelial cell proliferation that is involved in renal tubule morphogenesis.
1 Q8R1S4 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
13 A0A0B4JCQ4 (/IPI) A0A0B4JCZ8 (/IPI) A0A0B4JD47 (/IPI) A0A0B4K7H4 (/IPI) A0A0B4K7T1 (/IPI) A0A0B4K822 (/IPI) A0A0B4KED3 (/IPI) A0A0B4KEE8 (/IPI) A0A0B4KEK0 (/IPI) A0A0B4KEU9 (/IPI)
(3 more)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 Q5ZMW2 (/ISS) Q8R1S4 (/ISS)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
2 Q765P7 (/IDA) Q765P7 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q6P9S0 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 O43312 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8R1S4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O43312 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q6P9S0 (/IDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
1 Q8R1S4 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 O43312 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q8R1S4 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q6P9S0 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
1 O43312 (/TAS)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
1 Q6P9S0 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q6P9S0 (/ISO)