The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Glycoside hydrolase family 38, central domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Alpha-mannosidase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase. [EC:]
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
  • The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
  • It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site.
  • The enzyme is sensitive to swainsonine.
10 P27046 P28494 P49641 Q16706 Q197W7 Q197W7 Q24451 Q8BRK9 Q8BRK9 Q9LFR0
Alpha-mannosidase. [EC:]
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D- mannosides.
  • Also hydrolyzes alpha-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose.
4 Q1ZXI8 Q54YC4 Q54YF7 Q55ER0