The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 421: Inorganic phosphate transporter

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inorganic phosphate transmembrane transporter activity GO:0005315
Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
4 O42885 (/ISO) Q09852 (/ISO) Q9P6J9 (/ISO) Q9Y7Q9 (/ISO)
Inorganic phosphate transmembrane transporter activity GO:0005315
Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
2 P25297 (/IDA) P25297 (/IDA)
Inorganic phosphate transmembrane transporter activity GO:0005315
Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
2 P25297 (/IMP) P25297 (/IMP)
Inorganic phosphate transmembrane transporter activity GO:0005315
Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
2 Q8GYF4 (/ISS) Q96243 (/ISS)
Manganese ion transmembrane transporter activity GO:0005384
Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
2 P25297 (/IMP) P25297 (/IMP)
Selenite:proton symporter activity GO:0097079
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).
2 P25297 (/IDA) P25297 (/IDA)
Selenite:proton symporter activity GO:0097079
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).
2 P25297 (/IMP) P25297 (/IMP)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphate ion transmembrane transport GO:0035435
The process in which a phosphate is transported across a membrane.
4 O42885 (/ISO) Q09852 (/ISO) Q9P6J9 (/ISO) Q9Y7Q9 (/ISO)
Phosphate ion transport GO:0006817
The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P25297 (/IMP) P25297 (/IMP) Q8GYF4 (/IMP)
Polyphosphate metabolic process GO:0006797
The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid.
2 P25297 (/IMP) P25297 (/IMP)
Phosphate ion transport GO:0006817
The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P25297 (/IDA) P25297 (/IDA)
Manganese ion transport GO:0006828
The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P25297 (/IMP) P25297 (/IMP)
Plasma membrane selenite transport GO:0097080
The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane.
2 P25297 (/IMP) P25297 (/IMP)
Regulation of replicative cell aging GO:1900062
Any process that modulates the frequency, rate or extent of replicative cell aging.
2 P25297 (/IMP) P25297 (/IMP)
Phosphate ion transport GO:0006817
The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q96243 (/TAS)
Cellular response to phosphate starvation GO:0016036
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
1 Q96243 (/IEP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 P25297 (/HDA) P25297 (/HDA) Q9P6J9 (/HDA) Q9Y7Q9 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 O42885 (/ISO) Q09852 (/ISO) Q9P6J9 (/ISO) Q9Y7Q9 (/ISO)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
2 P25297 (/HDA) P25297 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q09852 (/HDA) Q9Y7Q9 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P25297 (/IDA) P25297 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q96243 (/IDA)