The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"MFS general substrate transporter like domains
".
FunFam 263: Proton-coupled folate transporter isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Folic acid transmembrane transporter activity GO:0008517
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
3 | Q5EBA8 (/IDA) Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Folic acid transmembrane transporter activity GO:0008517
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
3 | Q05B81 (/ISS) Q5EBA8 (/ISS) Q6PEM8 (/ISS) |
|
Folic acid transmembrane transporter activity GO:0008517
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | Q96NT5 (/IMP) Q96NT5 (/IMP) |
|
Folic acid transmembrane transporter activity GO:0008517
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | Q96NT5 (/TAS) Q96NT5 (/TAS) |
|
Proton transmembrane transporter activity GO:0015078
Enables the transfer of a proton from one side of a membrane to the other.
|
2 | Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Heme transporter activity GO:0015232
Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells.
|
2 | Q05B81 (/IDA) Q6PEM8 (/IDA) |
|
Heme transporter activity GO:0015232
Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells.
|
2 | Q96NT5 (/TAS) Q96NT5 (/TAS) |
|
Methotrexate transmembrane transporter activity GO:0015350
Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
2 | Q96NT5 (/IC) Q96NT5 (/IC) |
|
Folic acid transmembrane transporter activity GO:0008517
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
1 | Q6PEM8 (/ISO) |
|
Proton transmembrane transporter activity GO:0015078
Enables the transfer of a proton from one side of a membrane to the other.
|
1 | Q6PEM8 (/ISO) |
|
Heme transporter activity GO:0015232
Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells.
|
1 | Q5EBA8 (/ISS) |
|
Methotrexate transmembrane transporter activity GO:0015350
Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
1 | Q5EBA8 (/IDA) |
|
Methotrexate transmembrane transporter activity GO:0015350
Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
1 | Q6PEM8 (/ISO) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Folic acid transport GO:0015884
The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
3 | Q5EBA8 (/IDA) Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Folic acid transport GO:0015884
The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
3 | Q05B81 (/ISS) Q5EBA8 (/ISS) Q6PEM8 (/ISS) |
|
Methotrexate transport GO:0051958
The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
3 | Q5EBA8 (/IDA) Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
2 | Q96NT5 (/TAS) Q96NT5 (/TAS) |
|
Folic acid transport GO:0015884
The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | Q96NT5 (/IMP) Q96NT5 (/IMP) |
|
Heme transport GO:0015886
The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q05B81 (/IDA) Q6PEM8 (/IDA) |
|
Folic acid metabolic process GO:0046655
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | Q96NT5 (/TAS) Q96NT5 (/TAS) |
|
Methotrexate transport GO:0051958
The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
2 | Q96NT5 (/IMP) Q96NT5 (/IMP) |
|
Intestinal folate absorption GO:0098829
Uptake of folic into the blood by absorption from the small intestine.
|
2 | Q96NT5 (/IC) Q96NT5 (/IC) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
2 | Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Folate import across plasma membrane GO:1904447
The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol.
|
2 | Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Folic acid transport GO:0015884
The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
1 | Q6PEM8 (/ISO) |
|
Heme transport GO:0015886
The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q5EBA8 (/ISS) |
|
Methotrexate transport GO:0051958
The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
1 | Q6PEM8 (/ISO) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
1 | Q6PEM8 (/ISO) |
|
Folate import across plasma membrane GO:1904447
The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol.
|
1 | Q6PEM8 (/ISO) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q05B81 (/ISS) Q5EBA8 (/ISS) Q96NT5 (/ISS) Q96NT5 (/ISS) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
3 | Q6PEM8 (/IDA) Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q96NT5 (/IDA) Q96NT5 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q96NT5 (/TAS) Q96NT5 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q96NT5 (/HDA) Q96NT5 (/HDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | Q05B81 (/ISS) Q5EBA8 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q6PEM8 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6PEM8 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q6PEM8 (/ISO) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q5EBA8 (/IDA) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q6PEM8 (/ISO) |