The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 172: MFS multidrug resistance transporter

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
4 P40474 (/IMP) P53943 (/IMP) P53943 (/IMP) Q6FSQ7 (/IMP)
Monocarboxylic acid transmembrane transporter activity GO:0008028
Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.
2 P53943 (/IMP) P53943 (/IMP)
Solute:proton antiporter activity GO:0015299
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
2 Q6FNQ2 (/IMP) Q6FNQ2 (/IMP)
Cation transmembrane transporter activity GO:0008324
Enables the transfer of cation from one side of a membrane to the other.
1 P40474 (/IMP)
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
1 P40475 (/IMP)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
4 P40474 (/IMP) P40475 (/IMP) P53943 (/IMP) P53943 (/IMP)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
3 Q6FNQ2 (/IMP) Q6FNQ2 (/IMP) Q6FSQ7 (/IMP)
Membrane raft assembly GO:0001765
The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
2 Q59YT1 (/IMP) Q5A6P6 (/IMP)
Monocarboxylic acid transport GO:0015718
The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P53943 (/IMP) P53943 (/IMP)
Amino acid export across plasma membrane GO:0032973
The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.
2 P53943 (/IGI) P53943 (/IGI)
Amino acid export across plasma membrane GO:0032973
The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.
2 P53943 (/IMP) P53943 (/IMP)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
2 Q59YT1 (/IMP) Q5A6P6 (/IMP)
Cellular response to acetate GO:0071311
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.
2 Q6FNQ2 (/IMP) Q6FNQ2 (/IMP)
Ascospore wall assembly GO:0030476
The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
1 P40475 (/IGI)
Copper ion export GO:0060003
The directed movement of copper ions out of a cell or organelle.
1 P40474 (/IMP)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
1 P40474 (/IGI)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
1 P40474 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P40475 (/IDA) P53943 (/IDA) P53943 (/IDA) Q6FNQ2 (/IDA) Q6FNQ2 (/IDA) Q6FSQ7 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
4 P40474 (/HDA) P40475 (/HDA) P53943 (/HDA) P53943 (/HDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
2 P53943 (/HDA) P53943 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P53943 (/HDA) P53943 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P53943 (/HDA) P53943 (/HDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q6FNQ2 (/IDA) Q6FNQ2 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 Q59YT1 (/IDA) Q5A6P6 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P40474 (/IDA)