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CATH Superfamily 1.20.1250.20

MFS general substrate transporter like domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Dipeptide and tripeptide permease A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proton transmembrane transporter activity GO:0015078
Enables the transfer of a proton from one side of a membrane to the other.
 75 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(65 more)
Peptide:proton symporter activity GO:0015333
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.
 75 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(65 more)
Tripeptide transmembrane transporter activity GO:0042937
Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other.
 75 P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP)
(65 more)
Dipeptide transmembrane transporter activity GO:0071916
Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.
 75 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(65 more)
Proton transmembrane transporter activity GO:0015078
Enables the transfer of a proton from one side of a membrane to the other.
 42 P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP)
(32 more)
Symporter activity GO:0015293
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
 42 P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA)
(32 more)
Peptide:proton symporter activity GO:0015333
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.
 42 P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP)
(32 more)
Peptide:proton symporter activity GO:0015333
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.
 5 Q9KTB5 (/ISS) Q9KTB5 (/ISS) Q9KTB5 (/ISS) Q9KTB5 (/ISS) Q9KTB5 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 2 Q5M4H8 (/IPI) Q8EHE6 (/IPI)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dipeptide transmembrane transport GO:0035442
The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.
 75 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(65 more)
Tripeptide transmembrane transport GO:0035443
The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds.
 75 P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP) P36837 (/IMP)
(65 more)
Oligopeptide transport GO:0006857
The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
 42 P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA)
(32 more)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
 42 P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP) P77304 (/IMP)
(32 more)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
 33 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(23 more)
Peptide transport GO:0015833
The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 5 Q9KTB5 (/ISS) Q9KTB5 (/ISS) Q9KTB5 (/ISS) Q9KTB5 (/ISS) Q9KTB5 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 75 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(65 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 75 P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA) P36837 (/IDA)
(65 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 42 P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA) P77304 (/RCA)
(32 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 42 P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA) P77304 (/IDA)
(32 more)