The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 115: High-affinity glucose transporter

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fructose transmembrane transporter activity GO:0005353
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
2 A0A1D8PQJ5 (/IDA) A0A1D8PQJ5 (/IDA)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
2 A0A1D8PQJ5 (/IDA) A0A1D8PQJ5 (/IDA)
Glucose binding GO:0005536
Interacting selectively and non-covalently with the D- or L-enantiomer of glucose.
2 P10870 (/TAS) P10870 (/TAS)
Hexose transmembrane transporter activity GO:0015149
Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.
2 A0A1D8PQJ5 (/ISS) A0A1D8PQJ5 (/ISS)
Mannose transmembrane transporter activity GO:0015578
Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
2 A0A1D8PQJ5 (/IDA) A0A1D8PQJ5 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q5ANE1 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q5ANE1 (/ISS)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Detection of glucose GO:0051594
The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal.
6 P10870 (/IMP) P10870 (/IMP) Q12300 (/IMP) Q12300 (/IMP) Q6FNU3 (/IMP) Q6FNU3 (/IMP)
Glucose mediated signaling pathway GO:0010255
The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes.
4 P10870 (/IMP) P10870 (/IMP) Q12300 (/IMP) Q12300 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
3 A0A1D8PQJ5 (/IMP) A0A1D8PQJ5 (/IMP) Q5ANE1 (/IMP)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
2 A0A1D8PQJ5 (/IDA) A0A1D8PQJ5 (/IDA)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
2 A0A1D8PQJ5 (/IEP) A0A1D8PQJ5 (/IEP)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
2 A0A1D8PQJ5 (/ISS) A0A1D8PQJ5 (/ISS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 A0A1D8PQJ5 (/IMP) A0A1D8PQJ5 (/IMP)
Fructose transmembrane transport GO:0015755
The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
2 P10870 (/IMP) P10870 (/IMP)
Mannose transmembrane transport GO:0015761
The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
2 P10870 (/IMP) P10870 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 A0A1D8PQJ5 (/IMP) A0A1D8PQJ5 (/IMP)
Filamentous growth of a population of unicellular organisms in response to neutral pH GO:0036178
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.
2 A0A1D8PQJ5 (/IMP) A0A1D8PQJ5 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 A0A1D8PQJ5 (/IMP) A0A1D8PQJ5 (/IMP)
Cellular response to neutral pH GO:0036244
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
2 A0A1D8PQJ5 (/IMP) A0A1D8PQJ5 (/IMP)
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
2 P10870 (/IMP) P10870 (/IMP)
Detection of glucose GO:0051594
The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal.
2 P10870 (/IGI) P10870 (/IGI)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
2 P10870 (/IMP) P10870 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q5ANE1 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q5ANE1 (/ISS)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q5ANE1 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q5ANE1 (/IDA)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q5ANE1 (/ISS)
Glycolytic fermentation GO:0019660
Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.
1 Q5ANE1 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q5ANE1 (/IMP)
Filamentous growth of a population of unicellular organisms in response to heat GO:0036168
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature.
1 Q5ANE1 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5ANE1 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A1D8PQJ5 (/IDA) A0A1D8PQJ5 (/IDA) P10870 (/IDA) P10870 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
4 P10870 (/HDA) P10870 (/HDA) Q12300 (/HDA) Q12300 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q12300 (/IMP) Q12300 (/IMP)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q5ANE1 (/ISS)